Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 4/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.37 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.37 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9811971 | 0.93 | ABCB1 (0.42) | ABCB1KCNH2CYP1A2ALDH1A1CYP2D6 | |
| SCHEMBL9812019 | 0.85 | ABCB1 (0.43) | ABCB1KCNH2CYP1A2ALDH1A1CYP2D6 | |
| SCHEMBL9812018 | 0.85 | ABCB1 (0.43) | ABCB1KCNH2CYP1A2ALDH1A1CYP2D6 | |
| SCHEMBL9812070 | 0.82 | KCNH2 (0.41) | ABCB1KCNH2ALDH1A1ADRB2ADRB1 | |
| SCHEMBL9811944 | 0.81 | BCHE (0.42) | ABCB1KCNH2CYP1A2ALDH1A1CYP2D6 | |
| Hydrochloric Acid SCHEMBL9811907 | 0.81 | KCNH2 (0.41) | ABCB1KCNH2CYP1A2ALDH1A1CYP2D6 | |
| SCHEMBL9811896 | 0.81 | ABCB1 (0.40) | ABCB1KCNH2CYP1A2ALDH1A1CYP2D6 | |
| SCHEMBL9812058 | 0.80 | ABCB1 (0.46) | ABCB1KCNH2CYP1A2ALDH1A1CYP2D6 | |
| SCHEMBL9683741 | 0.79 | ABCB1 (0.36) | ABCB1KCNH2CYP1A2ALDH1A1CYP2D6 | |
| SCHEMBL9683733 | 0.79 | ABCB1 (0.36) | ABCB1KCNH2CYP1A2ALDH1A1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0170121-B1 | 2-HYDROXY-3-ARYLOXYPROPYL OR 2-HYDROXY-2-BENZOFURANYL ETHYL TERTIARY AMINE HAVING AN ANTI-HYPERGLYCAEMIC AND/OR ANTI-OBESITY ACTIVITY | BEECHAM GROUP PLC (GB) | 1991-06-19 | — | — | EP | claimed |
| EP-0170121-A1 | 2-Hydroxy-3-aryloxypropyl or 2-hydroxy-2-benzofuranyl ethyl tertiary amine having an anti-hyperglycaemic and/or anti-obesity activity | BEECHAM GROUP PLC (GB) | 1986-02-05 | — | — | EP | claimed |
| EP-0170121-B1 | 2-HYDROXY-3-ARYLOXYPROPYL OR 2-HYDROXY-2-BENZOFURANYL ETHYL TERTIARY AMINE HAVING AN ANTI-HYPERGLYCAEMIC AND/OR ANTI-OBESITY ACTIVITY | BEECHAM GROUP PLC (GB) | 1991-06-19 | — | — | EP | disclosed |
| EP-0170121-A1 | 2-Hydroxy-3-aryloxypropyl or 2-hydroxy-2-benzofuranyl ethyl tertiary amine having an anti-hyperglycaemic and/or anti-obesity activity | BEECHAM GROUP PLC (GB) | 1986-02-05 | — | — | EP | disclosed |