Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 6/20 | 0.45 |
| ▸ | MAPT | P10636 | 6/20 | 0.39 |
| ▸ | GAA | P10253 | 6/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | NOX1 | Q9Y5S8 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.39 |
| ▸ | SNCA | P37840 | 2/20 | 0.39 |
| ▸ | CYBB | P04839 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | NOX3 | Q9HBY0 | 1/20 | 0.39 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | BCHE | P06276 | 2/20 | 0.39 |
| ▸ | ACHE | P22303 | 2/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9813179 | 0.85 | NOX1 (0.44) | HPGDMAPTGAAKMT2ANOX1 | |
| SCHEMBL9813167 | 0.81 | NOX1 (0.41) | MAPTGAAKMT2ANOX1MEN1 | |
| SCHEMBL1509822 | 0.74 | NOX1 (0.47) | MAPTGAAKMT2ANOX1MEN1 | |
| SCHEMBL10788315 | 0.74 | KMT2A (0.58) | HPGDMAPTGAAKMT2ANOX1 | |
| SCHEMBL9813115 | 0.72 | NOX1 (0.52) | HPGDMAPTGAAKMT2ANOX1 | |
| SCHEMBL10500786 | 0.70 | MAPT (0.44) | HPGDMAPTGAAKMT2ANOX1 | |
| Benzophenone SCHEMBL28599856 | 0.68 | NOX1 (0.65) | MAPTGAAKMT2ANOX1MEN1 | |
| SCHEMBL20594004 | 0.66 | NOX1 (0.52) | MAPTGAAKMT2ANOX1MEN1 | |
| Phenothiazine SCHEMBL1509832 | 0.66 | NOX1 (0.74) | MAPTGAAKMT2ANOX1MEN1 | |
| SCHEMBL28614029 | 0.66 | NOX1 (0.46) | HPGDMAPTGAAKMT2ANOX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0138481-B1 | LEUKOTRIENE BIOSYNTHESIS INHIBITORS | MERCK FROSST CANADA INC. (CA) | 1991-06-26 | — | — | EP | disclosed |
| US-4845083-A | PHENOTHIAZINE DERIVATIVES AND ANALOGS | MERCK FROSST CANADA, INC. (CA) | 1989-07-04 | — | — | US | disclosed |
| EP-0138481-A2 | Leukotriene biosynthesis inhibitors | MERCK FROSST CANADA INC. (CA) | 1985-04-24 | — | — | EP | disclosed |