⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27886141 | 0.75 | — | — | |
| SCHEMBL10441951 | 0.71 | — | — | |
| SCHEMBL239357 | 0.67 | — | — | |
| SCHEMBL20271634 | 0.67 | — | — | |
| SCHEMBL7524674 | 0.67 | — | — | |
| SCHEMBL709674 | 0.67 | — | — | |
| SCHEMBL7513957 | 0.67 | — | — | |
| SCHEMBL4473440 | 0.67 | — | — | |
| SCHEMBL22802544 | 0.67 | — | — | |
| SCHEMBL8528087 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114890993-B | Chalcone phenazine hybrid molecule and application thereof | 中国药科大学 | 2023-03-31 | — | — | CN | disclosed |
| CN-110300589-B | Bicyclic heteroaryl derivatives as CFTR potentiators | 囊性纤维化基金会 | 2023-03-10 | — | — | CN | disclosed |
| CN-114890993-A | Chalcone phenazine hybrid molecule and application thereof | 中国药科大学 | 2022-08-12 | — | — | CN | disclosed |
| CN-106794362-B | Carbon monoxide-releasing molecules for therapeutic applications and methods of making and using the same | 乔治亚州立大学研究基金会股份有限公司 | 2021-07-06 | — | — | CN | disclosed |
| EP-3554506-B1 | BYCYCLIC HETEROARYL DERIVATIVES AS CFTR POTENTIATORS | CYSTIC FIBROSIS FOUND (US) | 2021-04-28 | — | — | EP | disclosed |
| US-10766904-B2 | Bicyclic heteroaryl derivatives as CFTR potentiators | CYSTIC FIBROSIS FOUNDATION (US) | 2020-09-08 | — | — | US | disclosed |
| US-20190330219-A1 | BICYCLIC HETEROARYL DERIVATIVES AS CFTR POTENTIATORS | PFIZER INC. | 2019-10-31 | — | — | US | disclosed |
| EP-3554506-A1 | BYCYCLIC HETEROARYL DERIVATIVES AS CFTR POTENTIATORS | Cystic Fibrosis Foundation Therapeutics, Inc. (US) | 2019-10-23 | — | — | EP | disclosed |
| US-10377762-B2 | Bicyclic heteroaryl derivatives as CFTR potentiators | CYSTIC FIBROSIS FOUNDATION (US) | 2019-08-13 | — | — | US | disclosed |
| US-10208053-B2 | Bicyclic heteroaryl derivatives as CFTR potentiators | CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. (US) | 2019-02-19 | — | — | US | disclosed |
| US-20190016727-A1 | BICYCLIC HETEROARYL DERIVATIVES AS CFTR POTENTIATORS | CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. (US) | 2019-01-17 | — | — | US | disclosed |
| US-20190016728-A1 | BICYCLIC HETEROARYL DERIVATIVES AS CFTR POTENTIATORS | CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. (US) | 2019-01-17 | — | — | US | disclosed |
| US-10131670-B2 | Bicyclic heteroaryl derivatives as CFTR potentiators | CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. (US) | 2018-11-20 | — | — | US | disclosed |
| US-20180170938-A1 | BICYCLIC HETEROARYL DERIVATIVES AS CFTR POTENTIATORS | CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. (US) | 2018-06-21 | — | — | US | disclosed |
| WO-2018112149-A1 | BYCYCLIC HETEROARYL DERIVATIVES AS CFTR POTENTIATORS | CYSTIC FIBROSIS FOUNDATON THERAPEUTICS INC. (US) | 2018-06-21 | — | — | WO | disclosed |
| CN-105884761-A | 6-O-demethylation side cryptaustoline derivative, application thereof, antiviral activity application and anticancer activity | 南开大学 | 2016-08-24 | — | — | CN | disclosed |
| EP-0262428-B1 | HYDANTOIN DERIVATIVES AND HERBICIDES CONTAINING THE DERIVATIVES AS AN ACTIVE INGREDIENT | SAGAMI CHEMICAL RESEARCH CENTER (JP) | 1991-08-14 | — | — | EP | disclosed |
| US-4902337-A | Herbicidal hydantoin derivatives | SAGAMI CHEMICAL RESEARCH (JP) | 1990-02-20 | — | — | US | disclosed |
| CN-87106076-A | Hydantoin derivative and be the weedicide of effective ingredient with this derivative | — | 1988-08-31 | — | — | CN | disclosed |
| EP-0262428-A1 | Hydantoin derivatives and herbicides containing the derivatives as an active ingredient | SAGAMI CHEMICAL RESEARCH CENTER (JP) | 1988-04-06 | — | — | EP | disclosed |