Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1L1 | Q9UHC9 | 9/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.41 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.40 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.36 |
| ▸ | POLA1 | P09884 | 1/20 | 0.35 |
| ▸ | TOP2A | P11388 | 1/20 | 0.35 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9814759 | 0.87 | P2RY12 (0.41) | NPC1L1LMNAMEN1USP2TP53 | |
| SCHEMBL9814676 | 0.82 | NPC1L1 (0.39) | NPC1L1LMNAMEN1USP2TP53 | |
| SCHEMBL14005008 | 0.80 | NPC1L1 (0.45) | NPC1L1LMNAMEN1USP2TP53 | |
| SCHEMBL10821097 | 0.79 | NPC1L1 (0.43) | NPC1L1LMNAMEN1USP2TP53 | |
| SCHEMBL10821098 | 0.79 | NPC1L1 (0.43) | NPC1L1LMNAMEN1USP2TP53 | |
| SCHEMBL9814579 | 0.79 | GRIN2B (0.36) | NPC1L1LMNAMEN1USP2TP53 | |
| SCHEMBL10874327 | 0.78 | NPC1L1 (0.40) | NPC1L1LMNAMEN1USP2TP53 | |
| SCHEMBL9814503 | 0.78 | NPC1L1 (0.40) | NPC1L1LMNAMEN1USP2TP53 | |
| SCHEMBL20855323 | 0.78 | GPBAR1 (0.45) | NPC1L1LMNAMEN1USP2TP53 | |
| SCHEMBL1885890 | 0.78 | GPBAR1 (0.45) | NPC1L1LMNAMEN1USP2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0201042-B1 | 3ALPHA,5-CYCLO-22,23-DIHYDROXY-5ALPHA,STEROID COMPOUNDS | FUJI YAKUHIN KOGYO KABUSHIKI KAISHA (JP) | 1991-08-28 | — | — | EP | claimed |
| US-4861875-A | 3α,5-cyclo-22,23-dihydroxy-5α-steroid compounds | FUJI YAKUHIN KOGYO KABUSHIKI KAISHA (JP) | 1989-08-29 | — | — | US | claimed |
| EP-0201042-A2 | 3alpha,5-Cyclo-22,23-dihydroxy-5alpha,steroid compounds | FUJI YAKUHIN KOGYO KABUSHIKI KAISHA (JP) | 1986-11-12 | — | — | EP | claimed |
| EP-0201042-B1 | 3ALPHA,5-CYCLO-22,23-DIHYDROXY-5ALPHA,STEROID COMPOUNDS | FUJI YAKUHIN KOGYO KABUSHIKI KAISHA (JP) | 1991-08-28 | — | — | EP | disclosed |
| US-4861875-A | 3α,5-cyclo-22,23-dihydroxy-5α-steroid compounds | FUJI YAKUHIN KOGYO KABUSHIKI KAISHA (JP) | 1989-08-29 | — | — | US | disclosed |
| EP-0201042-A2 | 3alpha,5-Cyclo-22,23-dihydroxy-5alpha,steroid compounds | FUJI YAKUHIN KOGYO KABUSHIKI KAISHA (JP) | 1986-11-12 | — | — | EP | disclosed |