Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 7/20 | 0.46 |
| ▸ | ESR1 | P03372 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | BLM | P54132 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | CGAS | Q8N884 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | GMNN | O75496 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.32 |
| ▸ | PDE1A | P54750 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9815619 | 0.92 | ESR2 (0.47) | ESR2ESR1MEN1KMT2AHSD17B10 | |
| SCHEMBL9815620 | 0.92 | ESR2 (0.47) | ESR2ESR1MEN1KMT2AHSD17B10 | |
| SCHEMBL10627581 | 0.87 | ESR2 (0.41) | ESR2ESR1MEN1KMT2AHSD17B10 | |
| SCHEMBL11111816 | 0.86 | ESR2 (0.52) | ESR2ESR1MEN1KMT2AHSD17B10 | |
| SCHEMBL10661757 | 0.85 | ESR2 (0.37) | ESR2ESR1MEN1KMT2AHSD17B10 | |
| SCHEMBL11264415 | 0.83 | MEN1 (0.50) | ESR2ESR1MEN1KMT2AHSD17B10 | |
| SCHEMBL11109377 | 0.83 | MEN1 (0.50) | ESR2ESR1MEN1KMT2AHSD17B10 | |
| SCHEMBL9813141 | 0.82 | ESR2 (0.47) | ESR2ESR1MEN1KMT2AHSD17B10 | |
| SCHEMBL11114155 | 0.82 | ESR2 (0.47) | ESR2ESR1MEN1KMT2AHSD17B10 | |
| SCHEMBL11114978 | 0.82 | ESR2 (0.47) | ESR2ESR1MEN1KMT2AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0217287-B1 | [(2,3,9,9a-tetrahydro-3-oxo-9a-substituted-1H-fluoren-7-yl)-oxy]ethanimidamides and [(2,3,9,9a-tetrahydro-3-oxo-9a-substituted-1H-fluoren-7yl)oxy]ethanimidic acid hydrazides, their derivatives and their salts | MERCK & CO. INC. (US) | 1991-06-26 | — | — | EP | disclosed |
| EP-0217287-A2 | [(2,3,9,9a-tetrahydro-3-oxo-9a-substituted-1H-fluoren-7-yl)-oxy]ethanimidamides and [(2,3,9,9a-tetrahydro-3-oxo-9a-substituted-1H-fluoren-7yl)oxy]ethanimidic acid hydrazides, their derivatives and their salts | MERCK & CO. INC. (US) | 1987-04-08 | — | — | EP | disclosed |
| US-4604396-A | TREATMENT OF GREY MATTER EDEMAS | MERCK & CO., INC. (US) | 1986-08-05 | — | — | US | disclosed |