Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.53 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 10/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | ALPL | P05186 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ALPI | P09923 | 1/20 | 0.37 |
| ▸ | ALPG | P10696 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | GCGR | P47871 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9818870 | 0.95 | PBRM1 (0.51) | PBRM1AKR1B1CNR1CNR2MAOB | |
| SCHEMBL9818866 | 0.95 | PBRM1 (0.51) | PBRM1AKR1B1CNR1CNR2MAOB | |
| SCHEMBL9819356 | 0.88 | PBRM1 (0.57) | PBRM1AKR1B1MAOBKDM4EALDH1A1 | |
| SCHEMBL9819094 | 0.86 | PBRM1 (0.58) | PBRM1AKR1B1CNR1CNR2MAOB | |
| SCHEMBL9818879 | 0.86 | PBRM1 (0.58) | PBRM1AKR1B1CNR1CNR2MAOB | |
| SCHEMBL10713025 | 0.83 | PBRM1 (0.55) | PBRM1AKR1B1CNR1CNR2MAOB | |
| SCHEMBL9818901 | 0.83 | PBRM1 (0.51) | PBRM1MAOBKDM4EALDH1A1GAA | |
| Lithium Ion SCHEMBL10713022 | 0.82 | PBRM1 (0.54) | PBRM1AKR1B1CNR1CNR2MAOB | |
| SCHEMBL9819184 | 0.81 | PBRM1 (0.53) | PBRM1CNR1CNR2MAOBKDM4E | |
| SCHEMBL9819284 | 0.81 | PBRM1 (0.60) | PBRM1AKR1B1CNR1CNR2MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0230379-B1 | CHROMAN- AND THIOCHROMAN-4-ACETIC ACIDS USEFUL IN THE TREATMENT OF DIABETIC COMPLICATIONS | PFIZER INC. (US) | 1991-04-03 | — | — | EP | disclosed |
| US-4853410-A | Hydroxyacetic acid derivatives for the treatment of diabetic complications | PFIZER INC. (US) | 1989-08-01 | — | — | US | disclosed |
| WO-1987004344-A1 | HYDROXYACETIC ACID DERIVATIVES FOR THE TREATMENT OF DIABETIC COMPLICATIONS | PFIZER INC. (US) | 1987-07-30 | — | — | WO | disclosed |
| EP-0230379-A2 | Chroman- and thiochroman-4-acetic acids useful in the treatment of diabetic complications | PFIZER INC. (US) | 1987-07-29 | — | — | EP | disclosed |