Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 7/20 | 0.38 |
| ▸ | BRD4 | O60885 | 6/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | TTR | P02766 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | ALPI | P09923 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13481989 | 0.75 | KDM4E (0.57) | PBRM1CYP19A1MAOAKDM4EPOLB | |
| SCHEMBL9819147 | 0.73 | PBRM1 (0.46) | PBRM1AKR1B1CNR1CNR2CREBBP | |
| SCHEMBL9818864 | 0.73 | SIRT2 (0.46) | PBRM1AKR1B1CNR1CNR2SMN1; SMN2 | |
| SCHEMBL9819187 | 0.73 | AKR1B1 (0.46) | PBRM1AKR1B1CNR1CNR2CREBBP | |
| SCHEMBL9819094 | 0.70 | PBRM1 (0.58) | PBRM1AKR1B1CNR1CNR2CREBBP | |
| SCHEMBL9818879 | 0.70 | PBRM1 (0.58) | PBRM1AKR1B1CNR1CNR2CREBBP | |
| SCHEMBL9818829 | 0.70 | PBRM1 (0.54) | PBRM1AKR1B1CNR1CNR2CYP19A1 | |
| SCHEMBL31110769 | 0.70 | PBRM1 (0.50) | PBRM1CNR1CNR2CREBBPBRD4 | |
| SCHEMBL10713025 | 0.68 | PBRM1 (0.55) | PBRM1AKR1B1CNR1CNR2CREBBP | |
| SCHEMBL1694255 | 0.67 | MAOB (0.42) | SMN1; SMN2MAOAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0230379-B1 | CHROMAN- AND THIOCHROMAN-4-ACETIC ACIDS USEFUL IN THE TREATMENT OF DIABETIC COMPLICATIONS | PFIZER INC. (US) | 1991-04-03 | — | — | EP | disclosed |
| US-4853410-A | Hydroxyacetic acid derivatives for the treatment of diabetic complications | PFIZER INC. (US) | 1989-08-01 | — | — | US | disclosed |
| WO-1987004344-A1 | HYDROXYACETIC ACID DERIVATIVES FOR THE TREATMENT OF DIABETIC COMPLICATIONS | PFIZER INC. (US) | 1987-07-30 | — | — | WO | disclosed |
| EP-0230379-A2 | Chroman- and thiochroman-4-acetic acids useful in the treatment of diabetic complications | PFIZER INC. (US) | 1987-07-29 | — | — | EP | disclosed |