Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 4/20 | 0.47 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALPL | P05186 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10712870 | 0.92 | PBRM1 (0.43) | AKR1B1PBRM1MAOAALDH1A1MAPT | |
| SCHEMBL9818957 | 0.84 | PBRM1 (0.48) | AKR1B1PBRM1MAOAALDH1A1CYP3A4 | |
| SCHEMBL9818879 | 0.83 | PBRM1 (0.58) | AKR1B1PBRM1MAOAALDH1A1CYP3A4 | |
| SCHEMBL9819094 | 0.83 | PBRM1 (0.58) | AKR1B1PBRM1MAOAALDH1A1CYP3A4 | |
| SCHEMBL9818954 | 0.83 | AKR1B1 (0.47) | AKR1B1PBRM1MAOAALDH1A1CYP3A4 | |
| SCHEMBL9818999 | 0.83 | PBRM1 (0.54) | AKR1B1PBRM1MAOAALDH1A1MAPT | |
| SCHEMBL19030678 | 0.81 | AKR1B1 (0.50) | AKR1B1MAOAALDH1A1CYP3A4MAPT | |
| SCHEMBL10713025 | 0.81 | PBRM1 (0.55) | AKR1B1PBRM1MAOAALDH1A1CYP3A4 | |
| Lithium Ion SCHEMBL10713022 | 0.79 | PBRM1 (0.54) | AKR1B1PBRM1MAOAALDH1A1CYP3A4 | |
| SCHEMBL9818870 | 0.77 | PBRM1 (0.51) | AKR1B1PBRM1ALDH1A1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0230379-B1 | CHROMAN- AND THIOCHROMAN-4-ACETIC ACIDS USEFUL IN THE TREATMENT OF DIABETIC COMPLICATIONS | PFIZER INC. (US) | 1991-04-03 | — | — | EP | disclosed |
| US-4853410-A | Hydroxyacetic acid derivatives for the treatment of diabetic complications | PFIZER INC. (US) | 1989-08-01 | — | — | US | disclosed |
| EP-0230379-A2 | Chroman- and thiochroman-4-acetic acids useful in the treatment of diabetic complications | PFIZER INC. (US) | 1987-07-29 | — | — | EP | disclosed |