SCHEMBL9822976

SCHEMBL9822976

COc1cc(OC)nc(NC(=O)NS(=O)(=O)c2ccccc2-c2nnnn2C)n1

nearest known ligand 0.52

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.50
CDK1 P06493 1/20 0.47
MAPT P10636 2/20 0.41
TP53 P04637 1/20 0.41
GLA P06280 1/20 0.41
ALDH1A1 P00352 2/20 0.39
HIF1A Q16665 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38
RXFP1 Q9HBX9 1/20 0.38
CYP1A2 P05177 1/20 0.38
KMT2A Q03164 1/20 0.38
KDM4E B2RXH2 1/20 0.38
NPC1 O15118 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9822877 0.95 GAA (0.45) GAACDK1MAPTTP53GLA
SCHEMBL9822721 0.94 GAA (0.45) GAACDK1MAPTTP53GLA
SCHEMBL9822821 0.88 GAA (0.43) GAAMAPTALDH1A1HIF1ANPSR1
SCHEMBL9756681 0.88 GAA (0.48) GAACDK1MAPTTP53GLA
SCHEMBL9822800 0.87 GAA (0.48) GAACDK1MAPTTP53GLA
SCHEMBL10766314 0.84 GAA (0.50) GAACDK1MAPTTP53GLA
SCHEMBL9435557 0.83 GAA (0.43) GAACDK1TP53ALDH1A1KDM4E
SCHEMBL9822859 0.82 GAA (0.53) GAACDK1MAPTTP53GLA
SCHEMBL9822901 0.82 GAA (0.44) GAACDK1MAPTTP53GLA
SCHEMBL10616134 0.82 GAA (0.67) GAACDK1MAPTTP53GLA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0204513-B1 HERBICIDAL SULFONAMIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1991-07-17 EP claimed
US-4746353-A Herbicidal sulfonamides E. I. DU PONT DE NEMOURS AND COMPANY (US) 1988-05-24 US claimed
EP-0204513-A2 Herbicidal sulfonamides E.I. DU PONT DE NEMOURS AND COMPANY (US) 1986-12-10 EP claimed
EP-0204513-B1 HERBICIDAL SULFONAMIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1991-07-17 EP disclosed
US-5017214-A Herbicidal sulfonamides LEVITT GEORGE (US) 1991-05-21 US disclosed
US-4913726-A PLANT GROWTH REGULATORS E. I. DU PONT DE NEMOURS AND COMPANY (US) 1990-04-03 US disclosed
US-4786311-A Herbicidal sulfonamides E. I. DU PONT DE NEMOURS AND COMPANY (US) 1988-11-22 US disclosed
US-4746353-A Herbicidal sulfonamides E. I. DU PONT DE NEMOURS AND COMPANY (US) 1988-05-24 US disclosed
EP-0204513-A2 Herbicidal sulfonamides E.I. DU PONT DE NEMOURS AND COMPANY (US) 1986-12-10 EP disclosed