Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.65 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.65 |
| ▸ | P2RX7 | Q99572 | 7/20 | 0.44 |
| ▸ | THRB | P10828 | 12/20 | 0.42 |
| ▸ | THRA | P10827 | 4/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6345637 | 0.91 | MEN1 (0.65) | MEN1NR1I2KMT2AP2RX7THRB | |
| SCHEMBL10394519 | 0.90 | MEN1 (0.64) | MEN1NR1I2KMT2AP2RX7THRB | |
| SCHEMBL10394517 | 0.90 | MEN1 (0.64) | MEN1NR1I2KMT2AP2RX7THRB | |
| SCHEMBL5566019 | 0.90 | MEN1 (0.64) | MEN1NR1I2KMT2AP2RX7THRB | |
| SCHEMBL10395297 | 0.88 | MEN1 (0.60) | MEN1NR1I2KMT2AP2RX7THRB | |
| SCHEMBL6490492 | 0.88 | MEN1 (0.56) | MEN1NR1I2KMT2AP2RX7THRB | |
| SCHEMBL5566328 | 0.87 | MEN1 (0.61) | MEN1NR1I2KMT2AP2RX7THRB | |
| SCHEMBL10394521 | 0.87 | MEN1 (0.61) | MEN1NR1I2KMT2AP2RX7THRB | |
| SCHEMBL5565958 | 0.87 | MEN1 (0.61) | MEN1NR1I2KMT2AP2RX7THRB | |
| SCHEMBL9823876 | 0.87 | MEN1 (0.61) | MEN1NR1I2KMT2AP2RX7THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0232932-B1 | 5,6-DIHYDRO-2-(SUBSTITUTED PHENYL)-1,2,4-TRIAZINE-3,5(2H,4H)-DIONES | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-01-02 | — | — | EP | disclosed |
| US-4952570-A | ANTIPROTOZOA AGENTS; COCCIDIOSIS | JANSSEN PHARMACEUTICA N.V. (BE) | 1990-08-28 | — | — | US | disclosed |
| US-4912106-A | 5,6-Dihydro-2-(substituted phenyl)-1,2,4-triazine-3,5,(2H,4H)-diones and their use as protozoa combating agents | JANSSEN PHARMACEUTICA N. V. FRAME-319 (BE) | 1990-03-27 | — | — | US | disclosed |
| US-4767760-A | Anti-protozoal 5,6-dihydro-2-(substituted phenyl)-1,2,4-triazine-3,5(2H,4H)-dione derivatives, compositions, and method of use therefor | JANSSEN PHARMACUETICA N.V. (BE) | 1988-08-30 | — | — | US | disclosed |
| EP-0232932-A1 | 5,6-Dihydro-2-(substituted phenyl)-1,2,4-triazine-3,5(2H,4H)-diones | JANSSEN PHARMACEUTICA N.V. (BE) | 1987-08-19 | — | — | EP | disclosed |