Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 11/20 | 0.59 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.50 |
| ▸ | AKR1A1 | P14550 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KIF11 | P52732 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6578015 | 0.87 | AKR1B1 (0.64) | AKR1B1AKR1B10AKR1A1MAPTCTNNB1 | |
| SCHEMBL10649371 | 0.82 | AKR1B1 (0.56) | AKR1B1AKR1B10AKR1A1MAPTCTNNB1 | |
| SCHEMBL10754110 | 0.82 | AKR1B1 (0.56) | AKR1B1AKR1B10AKR1A1MAPTCTNNB1 | |
| SCHEMBL11367364 | 0.82 | MAP3K14 (0.47) | AKR1B1MAPTTSHRNPC1RAB9A | |
| SCHEMBL7177095 | 0.82 | AKR1B1 (0.55) | AKR1B1AKR1B10AKR1A1MAPTNPC1 | |
| SCHEMBL9823995 | 0.81 | AKR1B1 (0.54) | AKR1B1AKR1B10AKR1A1MAPTCTNNB1 | |
| SCHEMBL10919189 | 0.77 | AKR1B1 (0.59) | AKR1B1AKR1B10AKR1A1MAPTCTNNB1 | |
| SCHEMBL10651444 | 0.77 | AKR1B1 (0.59) | AKR1B1AKR1B10AKR1A1MAPTCTNNB1 | |
| SCHEMBL10569394 | 0.77 | AKR1B1 (0.59) | AKR1B1AKR1B10AKR1A1MAPTCTNNB1 | |
| Hydrochloric Acid SCHEMBL10569320 | 0.75 | AKR1B1 (0.58) | AKR1B1AKR1B10AKR1A1MAPTCTNNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0193415-B1 | SPIRO-3-HETEROAZOLIDINE COMPOUNDS AND SALTS THEREOF, THEIR PREPARATION AND PHARMACEUTICAL AGENTS THEREOF | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1991-06-26 | — | — | EP | disclosed |
| US-4740517-A | INHIBIT ALDOSE REDUCTASE | SANWA KAGAKU KENYUSHO CO., LTD. (JP) | 1988-04-26 | — | — | US | disclosed |
| EP-0193415-A2 | Spiro-3-heteroazolidine compounds and salts thereof, their preparation and pharmaceutical agents thereof | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1986-09-03 | — | — | EP | disclosed |