Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.30 |
| ▸ | PGD | P52209 | 1/20 | 0.30 |
| ▸ | SRC | P12931 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10541398 | 0.98 | PDE4A (0.62) | PDE4ALMNAUSP2SLCO1B1TDP1 | |
| SCHEMBL9355908 | 0.91 | PDE4A (0.57) | PDE4ALMNAUSP2SLCO1B1TDP1 | |
| SCHEMBL16144900 | 0.91 | PDE4A (0.57) | PDE4ALMNAUSP2SLCO1B1TDP1 | |
| SCHEMBL7994016 | 0.91 | PDE4A (0.57) | PDE4ALMNAUSP2SLCO1B1TDP1 | |
| SCHEMBL28141188 | 0.91 | PDE4A (0.61) | PDE4ALMNAUSP2SLCO1B1TDP1 | |
| SCHEMBL11573173 | 0.90 | PDE4A (0.66) | PDE4ALMNAUSP2SLCO1B1TDP1 | |
| SCHEMBL17164507 | 0.90 | PDE4A (0.66) | PDE4ALMNAUSP2SLCO1B1TDP1 | |
| SCHEMBL7538632 | 0.90 | PDE4A (0.66) | PDE4ALMNAUSP2SLCO1B1TDP1 | |
| SCHEMBL4395512 | 0.89 | PDE4A (0.59) | PDE4ALMNAUSP2SLCO1B1TDP1 | |
| SCHEMBL1005420 | 0.89 | PDE4A (0.59) | PDE4ALMNAUSP2SLCO1B1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0228661-B1 | ISOXAZOLO-PYRIDO-BENZOXAZINE AND ISOTHIAZOLO-PYRIDO-BENZOXAZINE DERIVATIVES | ABBOTT LABORATORIES (US) | 1991-08-07 | — | — | EP | disclosed |
| EP-0227088-B1 | ISOXAZOLO-NAPHTHYRIDINE, ISOXAZOLO QUINOLINE, ISOTHIAZOLONAPHTHYRIDINE, AND ISOTHIAZOLOQUINOLINE DERIVATIVES | ABBOTT LABORATORIES (US) | 1991-08-07 | — | — | EP | disclosed |
| EP-0227039-B1 | ISOXAZOLO-PYRIDO-PHENOXAZINE AND ISOTHIAZOLO-PYRIDO-PHENOXAZINE DERIVATIVES | ABBOTT LABORATORIES (US) | 1991-08-07 | — | — | EP | disclosed |
| US-4767762-A | Tricyclic quinoline and naphthyride antibacterials | ABBOTT LABORATORIES (US) | 1988-08-30 | — | — | US | disclosed |
| US-4689325-A | Isoxazolo-pyrido-phenoxazine and isothiazolo-pyrido-phenoxazine derivatives | ABBOTT LABORATORIES (US) | 1987-08-25 | — | — | US | disclosed |
| US-4687770-A | Isoxazolo-pyrido-benzoxazine and isothiazolo-pyrido-benzoxazine derivatives | ABBOTT LABORATORIES (US) | 1987-08-18 | — | — | US | disclosed |
| EP-0228661-A1 | Isoxazolo-pyrido-benzoxazine and isothiazolo-pyrido-benzoxazine derivatives | ABBOTT LABORATORIES (US) | 1987-07-15 | — | — | EP | disclosed |
| EP-0227039-A1 | Isoxazolo-pyrido-phenoxazine and isothiazolo-pyrido-phenoxazine derivatives | ABBOTT LABORATORIES (US) | 1987-07-01 | — | — | EP | disclosed |
| EP-0227088-A1 | Isoxazolo-naphthyridine, isoxazolo quinoline, isothiazolonaphthyridine, and isothiazoloquinoline derivatives | ABBOTT LABORATORIES (US) | 1987-07-01 | — | — | EP | disclosed |