Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 6/20 | 0.78 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.78 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.78 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.78 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.78 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.78 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.78 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.78 |
| ▸ | MEN1 | O00255 | 1/20 | 0.78 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.78 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.78 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.78 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.78 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.63 |
| ▸ | DRD1 | P21728 | 1/20 | 0.61 |
| ▸ | DRD5 | P21918 | 1/20 | 0.61 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9824022 | 0.98 | CHRM2 (0.79) | CHRM2CHRM4CHRM1CHRM3CYP1A2 | |
| SCHEMBL9824922 | 0.95 | CHRM2 (0.81) | CHRM2CHRM4CHRM1CHRM3CYP1A2 | |
| SCHEMBL9823882 | 0.93 | CHRM2 (0.78) | CHRM2CHRM4CHRM1CHRM3CYP1A2 | |
| SCHEMBL9823891 | 0.93 | CHRM2 (0.78) | CHRM2CHRM4CHRM1CHRM3CYP1A2 | |
| SCHEMBL9824886 | 0.91 | CHRM2 (0.87) | CHRM2CHRM4CHRM1CHRM3CYP1A2 | |
| SCHEMBL9824031 | 0.91 | CHRM2 (0.77) | CHRM2CHRM4CHRM1CHRM3CYP1A2 | |
| SCHEMBL9824737 | 0.91 | CHRM2 (0.89) | CHRM2CHRM4CHRM1CHRM3CYP1A2 | |
| Hydrochloric Acid SCHEMBL9824499 | 0.90 | CHRM2 (0.88) | CHRM2CHRM4CHRM1CHRM3CYP1A2 | |
| SCHEMBL9824118 | 0.89 | CHRM2 (0.94) | CHRM2CHRM4CHRM1CHRM3CYP1A2 | |
| SCHEMBL9824786 | 0.89 | CHRM2 (0.79) | CHRM2CHRM4CHRM1CHRM3CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0273239-B1 | CONDENSED DIAZEPINONES, PROCESSES FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | Dr. Karl Thomae GmbH (DE) | 1991-03-06 | — | — | EP | disclosed |
| US-4873236-A | BRADYCARDIAL AGENTS | DR. KARL THOMAE GMBH (DE) | 1989-10-10 | — | — | US | disclosed |
| EP-0273239-A1 | Condensed diazepinones, processes for their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1988-07-06 | — | — | EP | disclosed |