Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.63 |
| ▸ | TSHR | P16473 | 2/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.63 |
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.63 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.54 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.53 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.53 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.53 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.53 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.53 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.53 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11040553 | 0.90 | MEN1 (0.62) | MEN1KMT2ATSHRSMN1; SMN2LMNA | |
| SCHEMBL9825269 | 0.88 | CRBN (0.58) | MEN1KMT2ATSHRSMN1; SMN2LMNA | |
| SCHEMBL9825127 | 0.86 | GRIN2B (0.66) | KMT2AMAPK1ALDH1A1 | |
| SCHEMBL9824610 | 0.84 | KMT2A (0.61) | MEN1KMT2AALDH1A1 | |
| Hydrochloric Acid SCHEMBL10682283 | 0.84 | GRIN2B (0.64) | KMT2AMAPK1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL10682276 | 0.84 | GRIN2B (0.64) | KMT2AMAPK1ALDH1A1 | |
| SCHEMBL20476353 | 0.83 | CRBN (0.49) | — | |
| SCHEMBL23143520 | 0.83 | GRIN1 (0.58) | MEN1KMT2ASMN1; SMN2ALDH1A1CA12 | |
| SCHEMBL29899541 | 0.83 | GRIN1 (0.58) | MEN1KMT2ASMN1; SMN2ALDH1A1CA12 | |
| Hydrochloric Acid SCHEMBL11044707 | 0.83 | MEN1 (0.59) | MEN1KMT2ATSHRSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0168003-B1 | OXINDOL COMPOUNDS, COMPOSITIONS CONTAINING SAME AND PROCESSES FOR PREPARING SAME | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1991-04-03 | — | — | EP | disclosed |
| US-4737501-A | Substituted piperazinyl oxindol compounds and cardiotonic compositions containing the same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1988-04-12 | — | — | US | disclosed |
| EP-0168003-A1 | Oxindol compounds, compositions containing same and processes for preparing same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1986-01-15 | — | — | EP | disclosed |