Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK7 | P49862 | 2/20 | 0.55 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.55 |
| ▸ | SIRT2 | Q8IXJ6 | 7/20 | 0.54 |
| ▸ | SIRT1 | Q96EB6 | 5/20 | 0.54 |
| ▸ | SIRT3 | Q9NTG7 | 3/20 | 0.54 |
| ▸ | TGM2 | P21980 | 1/20 | 0.54 |
| ▸ | CTSL | P07711 | 1/20 | 0.52 |
| ▸ | CTSS | P25774 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30902797 | 0.89 | MAPT (0.62) | KLK7KLK5MAPTSIRT5SIRT2 | |
| SCHEMBL12148814 | 0.89 | MAPT (0.62) | KLK7KLK5MAPTSIRT2SIRT1 | |
| SCHEMBL13599690 | 0.87 | MAPT (0.58) | KLK7KLK5MAPTSIRT5SIRT2 | |
| SCHEMBL30902907 | 0.87 | MAPT (0.65) | KLK7KLK5MAPTSIRT2SIRT1 | |
| SCHEMBL19851505 | 0.87 | SIRT2 (0.67) | SIRT2SIRT1SIRT3CTSLCTSS | |
| SCHEMBL5329057 | 0.86 | MAPT (0.59) | KLK7KLK5MAPTSIRT5SIRT2 | |
| SCHEMBL17039826 | 0.86 | FOLH1 (0.60) | KLK7KLK5MAPTSIRT5SIRT2 | |
| SCHEMBL5329053 | 0.86 | MAPT (0.59) | KLK7KLK5MAPTSIRT5SIRT2 | |
| SCHEMBL4857149 | 0.86 | MAPT (0.58) | KLK7KLK5MAPTSIRT2SIRT1 | |
| SCHEMBL2467817 | 0.86 | FOLH1 (0.65) | KLK7KLK5MAPTSIRT2SIRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0237082-B1 | 3,5-DISUBSTITUTED 4,5-DIHYDROISOXAZOLES AS TRANSGLUTAMINASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1991-05-29 | — | — | EP | disclosed |
| US-4929630-A | SKIN DISORDERS, ACNE, 4,5-DIHYDROISOOXAZOLE PEPTIDES | SYNTEX (U.S.A.) INC. (US) | 1990-05-29 | — | — | US | disclosed |
| US-4912120-A | Containing amine and amide substitution | SYNTEX (U.S.A.) INC. (US) | 1990-03-27 | — | — | US | disclosed |