Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 2/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 4/20 | 0.38 |
| ▸ | MAOA | P21397 | 2/20 | 0.33 |
| ▸ | MAOB | P27338 | 2/20 | 0.33 |
| ▸ | QPCT | Q16769 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19471071 | 0.78 | CHRM2 (0.46) | ATMCHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL17870932 | 0.78 | CHRM2 (0.46) | ATMCHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL19471088 | 0.74 | IDH1 (0.42) | NPSR1LMNA | |
| SCHEMBL10851533 | 0.74 | ATM (0.47) | ATMNPSR1RIPK1 | |
| SCHEMBL17870955 | 0.74 | IDH1 (0.42) | NPSR1LMNA | |
| SCHEMBL11283658 | 0.73 | SMN1; SMN2 (0.45) | ATMNPSR1LMNA | |
| SCHEMBL7352920 | 0.73 | ATM (0.49) | ATMNPSR1RIPK1QPCT | |
| SCHEMBL7829770 | 0.72 | ATM (0.48) | ATMNPSR1RIPK1 | |
| SCHEMBL11258889 | 0.71 | GAA (0.51) | ATM | |
| SCHEMBL10851613 | 0.71 | ATM (0.41) | ATMNPSR1RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0440670-A1 | HETEROCYCLIC ACETYLENIC AMINES HAVING CENTRAL NERVOUS SYSTEM ACTIVITY. | UPJOHN CO (US) | 1991-08-14 | — | — | EP | disclosed |