Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 2/20 | 0.61 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.61 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.61 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.61 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.52 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.52 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.52 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10411341 | 0.97 | PDE4A (0.57) | PDE4APDE4BPDE4CPDE4DCYP19A1 | |
| SCHEMBL9826497 | 0.94 | CYP19A1 (0.65) | PDE4APDE4BPDE4CPDE4DCYP19A1 | |
| SCHEMBL2221405 | 0.84 | KDM4E (0.59) | CYP19A1KDM4EATMPLAAT3PLAAT5 | |
| SCHEMBL30869991 | 0.83 | ATM (0.70) | CYP19A1KDM4EATMMAPT | |
| SCHEMBL10343404 | 0.83 | ATM (0.70) | CYP19A1KDM4EATMMAPT | |
| SCHEMBL5192275 | 0.83 | KDM4E (0.57) | CYP19A1KDM4EATMPLAAT3PLAAT5 | |
| SCHEMBL2224074 | 0.82 | ATM (0.61) | CYP19A1KDM4EATMPLAAT3PLAAT5 | |
| SCHEMBL23913120 | 0.81 | ATM (0.68) | CYP19A1KDM4EATMMAPT | |
| SCHEMBL31556190 | 0.81 | ATM (0.68) | CYP19A1KDM4EATMMAPT | |
| SCHEMBL31556187 | 0.81 | ATM (0.68) | CYP19A1KDM4EATMMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0221346-B1 | (N-SUBSTITUTED-2-HYDROXY) BENZAMIDES AND N-SUBSTITUTED-2-HYDROXY-ALPHA-OXO-BENZENEACETAMIDES AND PHARMACEUTICAL COMPOSITIONS THEREOF HAVING ACTIVITY AS MODULATORS OF THE ARACHIDONIC ACID CASCADE | WARNER-LAMBERT COMPANY (US) | 1991-01-30 | — | — | EP | disclosed |
| US-4939133-A | N-substituted-2-hydroxy-α-oxo-benzeneacetamides and pharmaceutical compositions having activity as modulators of the arachidonic acid cascade | WARNER-LAMBERT COMPANY (US) | 1990-07-03 | — | — | US | disclosed |
| US-4921871-A | LIPOXYGENASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1990-05-01 | — | — | US | disclosed |
| US-4868195-A | ENZYME INHIBITORS, ANTIALLERGEN, ASTHMA, CARDIOVASCULAR, ANTIINFLAMMATORY | WARNER-LAMBERT COMPANY (US) | 1989-09-19 | — | — | US | disclosed |
| US-4868200-A | LEUKOTRIENES, LIPOXYGENASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1989-09-19 | — | — | US | disclosed |
| US-4868205-A | ANTIALLERGENS, ANTIINFLAMMATORY, CARDIOVASCULAR DISORDERS | WARNER-LAMBERT COMPANY (US) | 1989-09-19 | — | — | US | disclosed |
| US-4868199-A | ENZYME INHIBITORS, ANTIALLERGEN, ASTHMA, CARDIOVASCULAR, ANTIINFLAMMATORY | WARNER-LAMBERT COMPANY (US) | 1989-09-19 | — | — | US | disclosed |
| US-4761424-A | Enolamides, pharmaceutical compositions and methods for treating inflammation | WARNER-LAMBERT COMPANY (US) | 1988-08-02 | — | — | US | disclosed |
| EP-0221346-A1 | (N-substituted-2-hydroxy) benzamides and N-substituted-2-hydroxy-alpha-oxo-benzeneacetamides and pharmaceutical compositions thereof having activity as modulators of the arachidonic acid cascade | WARNER-LAMBERT COMPANY (US) | 1987-05-13 | — | — | EP | disclosed |
| EP-0221345-A1 | Novel enolamides, process for their manufacture and pharmaceutical compositions thereof with an activity as modulators of the arachidonic acid cascade | WARNER-LAMBERT COMPANY (US) | 1987-05-13 | — | — | EP | disclosed |