Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.45 |
| ▸ | THRB | P10828 | 10/20 | 0.44 |
| ▸ | THRA | P10827 | 8/20 | 0.44 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PLA2G1B | P04054 | 3/20 | 0.38 |
| ▸ | ATG4B | Q9Y4P1 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9085264 | 0.87 | CYP4A11 (0.46) | CYP4A11THRBTHRACYP4F2MEN1 | |
| SCHEMBL7398278 | 0.83 | CYP4A11 (0.66) | CYP4A11THRBTHRACYP4F2MEN1 | |
| SCHEMBL9089230 | 0.82 | CYP4A11 (0.46) | CYP4A11THRBTHRACYP4F2CA12 | |
| SCHEMBL9089235 | 0.82 | CYP4A11 (0.46) | CYP4A11THRBTHRACYP4F2CA12 | |
| SCHEMBL7855043 | 0.81 | CYP4A11 (0.68) | CYP4A11CYP4F2CA12CA1CA2 | |
| SCHEMBL23710398 | 0.80 | TSHR (0.46) | CYP4A11THRBTHRACYP4F2MEN1 | |
| SCHEMBL8562574 | 0.80 | CYP4A11 (0.49) | CYP4A11THRBTHRACYP4F2CA12 | |
| SCHEMBL8570437 | 0.80 | CYP4A11 (0.49) | CYP4A11THRBTHRACYP4F2CA12 | |
| SCHEMBL8293510 | 0.80 | RARB (0.55) | CYP4A11THRBTHRACYP4F2MEN1 | |
| SCHEMBL1560634 | 0.80 | CYP4A11 (0.69) | CYP4A11THRBTHRACYP4F2CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0150892-B1 | SUBSTITUTED ALKYLIDENE IMIDAZOLES | G.D. Searle & Co. (US) | 1991-04-24 | — | — | EP | disclosed |
| US-4837333-A | SELECTIVE INHIBITOR OF THROMBOXANE SYNTHETASE ENZYME | G. D. SEARLE & CO. (US) | 1989-06-06 | — | — | US | disclosed |
| EP-0150892-A2 | Substituted alkylidene imidazoles | G.D. Searle & Co. (US) | 1985-08-07 | — | — | EP | disclosed |