Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Alcohol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 8/20 | 0.56 |
| ▸ | GPBAR1 | Q8TDU6 | 4/20 | 0.53 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.51 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.50 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.50 |
| ▸ | CYSLTR2 | Q9NS75 | 5/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9828316 | 0.96 | CYSLTR1 (0.54) | CYSLTR1GPBAR1ALOX5FFAR1AKR1B1 | |
| SCHEMBL9827588 | 0.87 | CYSLTR1 (0.65) | CYSLTR1GPBAR1ALOX5FFAR1AKR1B1 | |
| SCHEMBL9828870 | 0.83 | CYSLTR1 (0.76) | CYSLTR1GPBAR1ALOX5FFAR1AKR1B1 | |
| SCHEMBL8736103 | 0.82 | CYSLTR1 (0.62) | CYSLTR1GPBAR1ALOX5CYSLTR2 | |
| SCHEMBL9828160 | 0.78 | CYSLTR1 (0.72) | CYSLTR1GPBAR1ALOX5FFAR1AKR1B1 | |
| SCHEMBL9828370 | 0.77 | CYSLTR1 (0.58) | CYSLTR1GPBAR1ALOX5FFAR1AKR1B1 | |
| SCHEMBL9828376 | 0.77 | CYSLTR1 (0.58) | CYSLTR1GPBAR1ALOX5FFAR1AKR1B1 | |
| SCHEMBL9828760 | 0.77 | CYSLTR1 (0.74) | CYSLTR1GPBAR1ALOX5FFAR1AKR1B1 | |
| SCHEMBL9828937 | 0.76 | CYSLTR1 (0.60) | CYSLTR1GPBAR1ALOX5FFAR1AKR1B1 | |
| SCHEMBL9828413 | 0.76 | CYSLTR1 (0.60) | CYSLTR1GPBAR1ALOX5FFAR1AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5051427-A | Antiinflammatory agents and antiallergens | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1991-09-24 | — | — | US | disclosed |
| EP-0395697-A4 | QUINOLINE DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D 4? | — | 1991-03-13 | — | — | EP | disclosed |
| EP-0395697-A1 | QUINOLINE DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D 4 | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1990-11-07 | — | — | EP | disclosed |
| WO-1989004303-A1 | QUINOLINE DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D4 | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1989-05-18 | — | — | WO | disclosed |