Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 6/20 | 0.44 |
| ▸ | LMNA | P02545 | 5/20 | 0.44 |
| ▸ | CDC25B | P30305 | 1/20 | 0.44 |
| ▸ | DPP4 | P27487 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | ERN1 | O75460 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CA7 | P43166 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5178794 | 0.87 | TSHR (0.49) | TSHRLMNADPP4ALDH1A1HSD17B10 | |
| SCHEMBL1809516 | 0.87 | TSHR (0.49) | TSHRHSD17B2MAPTLMNACDC25B | |
| SCHEMBL129924 | 0.83 | TSHR (0.60) | TSHRMAPTLMNACDC25BALDH1A1 | |
| SCHEMBL182737 | 0.83 | KDM4E (0.44) | TSHRMAPTLMNAALDH1A1HSD17B10 | |
| SCHEMBL22042157 | 0.82 | TSHR (0.44) | TSHRALDH1A1HSD17B10CA12CA1 | |
| SCHEMBL29258466 | 0.81 | TSHR (0.53) | TSHRMAPTLMNACDC25BALDH1A1 | |
| SCHEMBL7499134 | 0.81 | TSHR (0.53) | TSHRLMNACDC25BALDH1A1HSD17B10 | |
| SCHEMBL1205732 | 0.80 | CA12 (0.56) | TSHRHSD17B2MAPTALDH1A1HSD17B10 | |
| SCHEMBL7355446 | 0.79 | HTT (0.46) | MAPTLMNAALDH1A1HSD17B10GAA | |
| SCHEMBL27897937 | 0.79 | TSHR (0.50) | TSHRLMNAALDH1A1HSD17B10TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0150892-B1 | SUBSTITUTED ALKYLIDENE IMIDAZOLES | G.D. Searle & Co. (US) | 1991-04-24 | — | — | EP | disclosed |
| US-4837333-A | SELECTIVE INHIBITOR OF THROMBOXANE SYNTHETASE ENZYME | G. D. SEARLE & CO. (US) | 1989-06-06 | — | — | US | disclosed |
| EP-0150892-A2 | Substituted alkylidene imidazoles | G.D. Searle & Co. (US) | 1985-08-07 | — | — | EP | disclosed |
| US-3953604-A | INHALATION, ANTI-ASTHMA | MILES LABORATORIES, INC. (US) | 1976-04-27 | — | — | US | disclosed |