Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.69 |
| ▸ | MAPT | P10636 | 6/20 | 0.64 |
| ▸ | MEN1 | O00255 | 6/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.64 |
| ▸ | NPC1 | O15118 | 3/20 | 0.64 |
| ▸ | RAB9A | P51151 | 3/20 | 0.64 |
| ▸ | LMNA | P02545 | 4/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | HTR7 | P34969 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | HTR1D | P28221 | 1/20 | 0.48 |
| ▸ | HTR1B | P28222 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11358434 | 0.90 | GAA (0.71) | GAAMAPTMEN1KMT2ANPC1 | |
| SCHEMBL11355335 | 0.89 | GAA (0.69) | GAAMAPTMEN1KMT2ANPC1 | |
| SCHEMBL9828796 | 0.87 | GAA (0.67) | GAAMAPTMEN1KMT2ANPC1 | |
| SCHEMBL9828806 | 0.87 | GAA (0.67) | GAAMAPTMEN1KMT2ANPC1 | |
| SCHEMBL11350274 | 0.86 | NPC1 (0.79) | GAAMAPTMEN1KMT2ANPC1 | |
| SCHEMBL9828815 | 0.86 | GAA (0.65) | GAAMAPTMEN1KMT2ANPC1 | |
| SCHEMBL10744968 | 0.85 | GAA (0.71) | GAAMAPTMEN1KMT2ANPC1 | |
| Iodide SCHEMBL10555753 | 0.85 | GAA (0.64) | GAAMAPTMEN1KMT2ANPC1 | |
| Hydrochloric Acid SCHEMBL10553975 | 0.84 | GAA (0.63) | GAAMAPTMEN1KMT2ANPC1 | |
| SCHEMBL2531516 | 0.82 | GAA (1.00) | GAAMAPTMEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0225726-B1 | INDOLE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1991-04-17 | — | — | EP | disclosed |
| US-4833153-A | VASOCONSTRICTORS, MIGRAINES | GLAXO GROUP LIMITED (GB) | 1989-05-23 | — | — | US | disclosed |
| EP-0225726-A1 | Indole derivatives | GLAXO GROUP LIMITED (GB) | 1987-06-16 | — | — | EP | disclosed |