Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 11/20 | 0.65 |
| ▸ | GPBAR1 | Q8TDU6 | 5/20 | 0.65 |
| ▸ | CYSLTR2 | Q9NS75 | 8/20 | 0.57 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9828376 | 0.93 | CYSLTR1 (0.58) | CYSLTR1GPBAR1CYSLTR2ALOX5 | |
| SCHEMBL7011355 | 0.92 | CYSLTR1 (0.66) | CYSLTR1GPBAR1CYSLTR2ALOX5 | |
| SCHEMBL6177226 | 0.90 | CYSLTR1 (0.64) | CYSLTR1GPBAR1CYSLTR2 | |
| SCHEMBL9829628 | 0.84 | CYSLTR1 (0.58) | CYSLTR1GPBAR1CYSLTR2ALOX5 | |
| SCHEMBL9829622 | 0.84 | CYSLTR1 (0.58) | CYSLTR1GPBAR1CYSLTR2ALOX5 | |
| SCHEMBL9032353 | 0.82 | CYSLTR1 (0.62) | CYSLTR1GPBAR1CYSLTR2 | |
| SCHEMBL9032345 | 0.82 | CYSLTR1 (0.62) | CYSLTR1GPBAR1CYSLTR2 | |
| SCHEMBL8321128 | 0.81 | CYSLTR1 (0.76) | CYSLTR1GPBAR1CYSLTR2ALOX5 | |
| SCHEMBL6089132 | 0.80 | CYSLTR1 (0.62) | CYSLTR1GPBAR1CYSLTR2ALOX5 | |
| Hydrochloric Acid SCHEMBL9828327 | 0.79 | CYSLTR1 (0.53) | CYSLTR1GPBAR1CYSLTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5051427-A | Antiinflammatory agents and antiallergens | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1991-09-24 | — | — | US | disclosed |
| EP-0395697-A4 | QUINOLINE DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D 4? | — | 1991-03-13 | — | — | EP | disclosed |
| EP-0395697-A1 | QUINOLINE DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D 4 | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1990-11-07 | — | — | EP | disclosed |
| US-4920133-A | Quinoline derivatives and use thereof as antagonists of leukotriene D4 | RORER PHARMACEUTICAL CORP. (US) | 1990-04-24 | — | — | US | disclosed |
| WO-1989004303-A1 | QUINOLINE DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D4 | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1989-05-18 | — | — | WO | disclosed |