Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 19/20 | 0.66 |
| ▸ | PIK3CA | P42336 | 14/20 | 0.61 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.57 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.57 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL986698 | 0.93 | MTOR (0.66) | MTORPIK3CAPIK3CDPIK3R1SMG1 | |
| SCHEMBL986926 | 0.90 | MTOR (0.81) | MTORPIK3CA | |
| SCHEMBL986009 | 0.90 | MTOR (0.63) | MTORPIK3CAPIK3CDPIK3R1SMG1 | |
| SCHEMBL985776 | 0.84 | MTOR (0.67) | MTORPIK3CAPIK3CD | |
| SCHEMBL987180 | 0.82 | MTOR (0.61) | MTORPIK3CAPIK3CDPIK3R1SMG1 | |
| SCHEMBL984817 | 0.81 | MTOR (0.51) | MTORPIK3CAPIK3R1 | |
| SCHEMBL3782857 | 0.81 | MTOR (0.89) | MTORPIK3CA | |
| SCHEMBL3782998 | 0.81 | MTOR (0.89) | MTORPIK3CA | |
| SCHEMBL3788682 | 0.81 | MTOR (0.89) | MTORPIK3CA | |
| SCHEMBL7762337 | 0.81 | MTOR (0.89) | MTORPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012099581-A1 | DIHYDROFUROPYRIMIDINE COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-07-26 | — | — | WO | claimed |
| US-20110021515-A1 | DIHYROFUROPYRMINDINE COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-01-27 | — | — | US | claimed |
| WO-2012099581-A1 | DIHYDROFUROPYRIMIDINE COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-07-26 | — | — | WO | disclosed |
| WO-2012099581-A1 | DIHYDROFUROPYRIMIDINE COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-07-26 | — | — | WO | disclosed |
| US-20110021515-A1 | DIHYROFUROPYRMINDINE COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-01-27 | — | — | US | disclosed |
| US-20110021515-A1 | DIHYROFUROPYRMINDINE COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-01-27 | — | — | US | disclosed |
| US-20110021515-A1 | DIHYROFUROPYRMINDINE COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110021515-A1 | DIHYROFUROPYRMINDINE COMPOUNDS | MTOR, RICTOR, DEPTOR | MTOR 1/4885PIK3CA 59/4885PIK3CD 42/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.