Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.51 |
| ▸ | MMP3 | P08254 | 1/20 | 0.51 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.47 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.47 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.47 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9829308 | 1.00 | PLK1 (0.54) | PLK1HDAC8MMP3NR4A1NR4A2 | |
| SCHEMBL10662287 | 0.81 | SMN1; SMN2 (0.51) | MEN1KMT2ANPC1RAB9AHPGD | |
| SCHEMBL9831154 | 0.81 | SMN1; SMN2 (0.51) | MEN1KMT2ANPC1RAB9AHPGD | |
| SCHEMBL6464894 | 0.80 | PLK1 (0.66) | PLK1HDAC8MMP3NR4A1NR4A2 | |
| SCHEMBL5580414 | 0.77 | CCR3 (0.48) | MEN1KMT2AGAA | |
| SCHEMBL5580412 | 0.77 | CCR3 (0.48) | MEN1KMT2AGAA | |
| SCHEMBL9828829 | 0.77 | POLB (0.57) | HDAC8KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL9828824 | 0.77 | POLB (0.57) | HDAC8KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL27693288 | 0.75 | CXCR2 (0.54) | CXCR2MEN1KMT2ANPC1RAB9A | |
| SCHEMBL10587317 | 0.73 | PLK1 (0.66) | PLK1HDAC8MMP3NR4A1NR4A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0226304-B1 | COMPOSITION CONTAINING A PENEM OR CARBAPENEM ANTIBIOTIC | SANKYO COMPANY LIMITED (JP) | 1991-08-28 | — | — | EP | disclosed |
| US-4757066-A | Reduces renal toxicity | SANKYO COMPANY LIMITED (JP) | 1988-07-12 | — | — | US | disclosed |
| EP-0226304-A1 | Composition containing a penem or carbapenem antibiotic | SANKYO COMPANY LIMITED (JP) | 1987-06-24 | — | — | EP | disclosed |