Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA9 | Q16790 | 6/20 | 0.56 |
| ▸ | CA1 | P00915 | 1/20 | 0.56 |
| ▸ | CA2 | P00918 | 1/20 | 0.56 |
| ▸ | CA5A | P35218 | 1/20 | 0.56 |
| ▸ | CA12 | O43570 | 5/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14086598 | 0.81 | CA1 (0.58) | CA9CA1CA2CA5ANPC1 | |
| SCHEMBL975460 | 0.79 | CA9 (0.73) | CA9CA1CA2CA5ACA12 | |
| SCHEMBL3256951 | 0.78 | CA1 (0.67) | CA9CA1CA2CA5ANPC1 | |
| SCHEMBL21268180 | 0.78 | CA1 (0.67) | CA9CA1CA2CA5ANPC1 | |
| SCHEMBL6535568 | 0.77 | CA1 (0.66) | CA9CA1CA2CA5ANPC1 | |
| SCHEMBL5691027 | 0.76 | CA1 (0.65) | CA9CA1CA2CA5ANPC1 | |
| SCHEMBL9683306 | 0.76 | CA1 (0.70) | CA9CA1CA2CA5ANPC1 | |
| SCHEMBL9829113 | 0.76 | CA1 (0.52) | CA9CA1CA2CA5ANPC1 | |
| SCHEMBL6038746 | 0.76 | CA1 (0.69) | CA9CA1CA2CA5ANPC1 | |
| SCHEMBL11661242 | 0.76 | CA1 (0.73) | CA9CA1CA2CA5ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0200408-B1 | INHIBITORS OF 5-LIPOXYGENASE | Pfizer Corporation (PA) | 1991-11-13 | — | — | EP | disclosed |
| US-4694080-A | LIPOXYGENASE INHIBITORS, BRONCHODILATOR, AND ANTIALLERGENS | PFIZER INC. (US) | 1987-09-15 | — | — | US | disclosed |
| EP-0200408-A1 | Inhibitors of 5-lipoxygenase | Pfizer Corporation (PA) | 1986-11-05 | — | — | EP | disclosed |