Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | LTA4H | P09960 | 2/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.34 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CYP4Z1 | Q86W10 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9830030 | 0.92 | SMN1; SMN2 (0.41) | SMN1; SMN2CYP1A2CYP2C19CYP3A4ALOX5 | |
| SCHEMBL9831024 | 0.88 | SMN1; SMN2 (0.42) | SMN1; SMN2PLA2G2ABLMCYP1A2CYP2C19 | |
| SCHEMBL10408081 | 0.87 | SMN1; SMN2 (0.48) | SMN1; SMN2ALOX5LTA4HPPARGALDH1A1 | |
| SCHEMBL10407546 | 0.86 | SMN1; SMN2 (0.46) | SMN1; SMN2CYP1A2CYP2C19ALOX5LTA4H | |
| SCHEMBL9831883 | 0.86 | SMN1; SMN2 (0.44) | SMN1; SMN2PLA2G2ABLMALOX5LTA4H | |
| SCHEMBL9830014 | 0.85 | SMN1; SMN2 (0.39) | SMN1; SMN2CYP1A2CYP2C19CYP3A4ALOX5 | |
| SCHEMBL10407589 | 0.83 | SMN1; SMN2 (0.43) | SMN1; SMN2PLA2G2ABLMALOX5LTA4H | |
| SCHEMBL10407235 | 0.83 | SMN1; SMN2 (0.43) | SMN1; SMN2PLA2G2ABLMALOX5LTA4H | |
| SCHEMBL9832100 | 0.83 | SMN1; SMN2 (0.43) | SMN1; SMN2ALOX5LTA4HPPARGALDH1A1 | |
| SCHEMBL9831533 | 0.82 | SMN1; SMN2 (0.42) | SMN1; SMN2PLA2G2ABLMCYP1A2ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449989-A1 | 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES | Sloan-Kettering Institute For Cancer Research (US) | 1991-10-09 | — | — | EP | disclosed |
| WO-1990007496-A1 | 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-07-12 | — | — | WO | disclosed |
| US-4925939-A | 6,7-dihydropyrrol[3,4-c]pyrido[2,3-d]pyrimidine derivatives | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-05-15 | — | — | US | disclosed |