Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 1/20 | 0.47 |
| ▸ | CES2 | O00748 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26941542 | 0.87 | LSS (0.44) | LSSCES2HTTMEN1THRB | |
| SCHEMBL1150489 | 0.84 | LSS (0.49) | LSSCES2HTTMEN1THRB | |
| SCHEMBL13380892 | 0.84 | — | — | |
| SCHEMBL9396040 | 0.83 | LSS (0.51) | LSSCES2HTTMEN1THRB | |
| SCHEMBL28264229 | 0.83 | LSS (0.51) | LSSCES2HTTMEN1THRB | |
| SCHEMBL29048956 | 0.83 | LSS (0.51) | LSSCES2HTTMEN1THRB | |
| Pentane SCHEMBL28776059 | 0.83 | LSS (0.47) | LSSCES2HTTMEN1THRB | |
| SCHEMBL5132941 | 0.82 | LSS (0.51) | LSSCES2HTTMEN1THRB | |
| SCHEMBL5132943 | 0.82 | LSS (0.51) | LSSCES2HTTMEN1THRB | |
| SCHEMBL6751726 | 0.81 | LSS (0.46) | LSSCES2HTTMEN1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2451461-A1 | NOVEL NUCLEIC ACID PRODRUGS AND METHODS OF USE THEREOF | Ontorii, Inc (US) | 2012-05-16 | — | — | EP | disclosed |
| WO-2011005761-A1 | NOVEL NUCLEIC ACID PRODRUGS AND METHODS USE THEREOF | ONTORII, INC (US) | 2011-01-13 | — | — | WO | disclosed |