Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.73 |
| ▸ | NPC1 | O15118 | 6/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.65 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.65 |
| ▸ | HPGD | P15428 | 1/20 | 0.65 |
| ▸ | GAA | P10253 | 2/20 | 0.62 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.62 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.60 |
| ▸ | RAB9A | P51151 | 5/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14088974 | 1.00 | KDM4E (0.73) | KDM4ENPC1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL9829545 | 0.98 | KDM4E (0.76) | KDM4ENPC1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL8144689 | 0.94 | KDM4E (0.78) | KDM4ENPC1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL6127192 | 0.91 | KDM4E (0.89) | KDM4ENPC1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL12491240 | 0.87 | KDM4E (0.72) | KDM4ENPC1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL24653254 | 0.84 | KDM4E (0.68) | KDM4ENPC1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL6928579 | 0.83 | KDM4E (0.76) | KDM4ENPC1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL5246151 | 0.81 | KDM4E (0.78) | KDM4ENPC1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL18906066 | 0.81 | KDM4E (0.83) | KDM4ENPC1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL711885 | 0.81 | NPC1 (0.91) | KDM4ENPC1CYP1A2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0226304-B1 | COMPOSITION CONTAINING A PENEM OR CARBAPENEM ANTIBIOTIC | SANKYO COMPANY LIMITED (JP) | 1991-08-28 | — | — | EP | disclosed |
| US-4757066-A | Reduces renal toxicity | SANKYO COMPANY LIMITED (JP) | 1988-07-12 | — | — | US | disclosed |
| EP-0226304-A1 | Composition containing a penem or carbapenem antibiotic | SANKYO COMPANY LIMITED (JP) | 1987-06-24 | — | — | EP | disclosed |