Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | LTA4H | P09960 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | GBA1 | P04062 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17415 | 0.89 | POLB (0.58) | POLBLTA4HMEN1KMT2AGBA1 | |
| SCHEMBL3495180 | 0.89 | POLB (0.58) | POLBLTA4HMEN1KMT2AGBA1 | |
| SCHEMBL16738 | 0.89 | POLB (0.58) | POLBLTA4HMEN1KMT2AGBA1 | |
| SCHEMBL29119634 | 0.87 | POLB (0.56) | POLBLTA4HMEN1KMT2AGBA1 | |
| Hydrochloric Acid SCHEMBL12078757 | 0.87 | POLB (0.56) | POLBLTA4HMEN1KMT2AGBA1 | |
| Hydrochloric Acid SCHEMBL12078541 | 0.87 | POLB (0.56) | POLBLTA4HMEN1KMT2AGBA1 | |
| SCHEMBL8904123 | 0.87 | POLB (0.56) | POLBLTA4HMEN1KMT2AGBA1 | |
| SCHEMBL8201261 | 0.87 | POLB (0.56) | POLBLTA4HMEN1KMT2AGBA1 | |
| SCHEMBL30589117 | 0.87 | POLB (0.56) | POLBLTA4HMEN1KMT2AGBA1 | |
| Hydrochloric Acid SCHEMBL8501825 | 0.81 | POLB (0.46) | POLBLTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0187371-B1 | SUBSTITUTED ISOQUINOLINESULFONYL COMPOUNDS | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1991-06-19 | — | — | EP | disclosed |
| US-4678783-A | CARDIOVASCULAR DISORDERS, HYPOTENSIVES, ARTERIOSCLEROSIS | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1987-07-07 | — | — | US | disclosed |
| EP-0187371-A2 | Substituted isoquinolinesulfonyl compounds | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1986-07-16 | — | — | EP | disclosed |