Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 2/20 | 0.41 |
| ▸ | NLRP3 | Q96P20 | 3/20 | 0.40 |
| ▸ | CYP4F2 | P78329 | 3/20 | 0.39 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | PPID | Q08752 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | TOP2A | P11388 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9833415 | 0.91 | SMN1; SMN2 (0.46) | SMN1; SMN2ALOX5LTA4HNLRP3CYP4F2 | |
| SCHEMBL9832361 | 0.87 | SMN1; SMN2 (0.41) | SMN1; SMN2ALOX5LTA4HNLRP3CYP4F2 | |
| SCHEMBL9831853 | 0.85 | SMN1; SMN2 (0.44) | SMN1; SMN2ALOX5LTA4HNLRP3CYP4F2 | |
| SCHEMBL9829742 | 0.84 | SMN1; SMN2 (0.49) | SMN1; SMN2ALOX5LTA4HCYP4F2CYP4A11 | |
| SCHEMBL9832157 | 0.82 | SMN1; SMN2 (0.60) | SMN1; SMN2ALOX5LTA4HCYP4F2CYP4A11 | |
| SCHEMBL11141812 | 0.82 | ESR1 (0.40) | ALDH1A1MAPTTP53CYP3A4TDP1 | |
| SCHEMBL9829514 | 0.80 | SMN1; SMN2 (0.50) | SMN1; SMN2ALOX5LTA4HALDH1A1HSD17B10 | |
| SCHEMBL341369 | 0.79 | TDP1 (0.41) | SMN1; SMN2ALDH1A1HSD17B10MAPTTP53 | |
| SCHEMBL11138800 | 0.79 | ELANE (0.41) | ALDH1A1MAPTTP53CYP3A4POLB | |
| SCHEMBL10407520 | 0.79 | SMN1; SMN2 (0.49) | SMN1; SMN2ALOX5LTA4HMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449989-A1 | 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES | Sloan-Kettering Institute For Cancer Research (US) | 1991-10-09 | — | — | EP | disclosed |
| WO-1990007496-A1 | 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-07-12 | — | — | WO | disclosed |
| US-4925939-A | 6,7-dihydropyrrol[3,4-c]pyrido[2,3-d]pyrimidine derivatives | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-05-15 | — | — | US | disclosed |