Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 5/20 | 0.54 |
| ▸ | NPC1 | O15118 | 4/20 | 0.54 |
| ▸ | TSHR | P16473 | 3/20 | 0.54 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11974036 | 0.83 | HTT (0.71) | HTTALDH1A1NPSR1RAB9ANPC1 | |
| SCHEMBL26227594 | 0.83 | HTT (0.71) | HTTALDH1A1NPSR1RAB9ANPC1 | |
| SCHEMBL2031143 | 0.82 | HTT (0.76) | HTTALDH1A1NPSR1RAB9ANPC1 | |
| SCHEMBL26227589 | 0.81 | HTT (0.69) | HTTALDH1A1NPSR1RAB9ANPC1 | |
| SCHEMBL12018996 | 0.80 | HTT (1.00) | HTTALDH1A1NPSR1RAB9ANPC1 | |
| SCHEMBL19736942 | 0.80 | HTT (0.67) | HTTALDH1A1NPSR1RAB9ANPC1 | |
| SCHEMBL6621432 | 0.80 | HTT (0.67) | HTTALDH1A1NPSR1RAB9ANPC1 | |
| SCHEMBL19991262 | 0.80 | HTT (0.67) | HTTALDH1A1NPSR1RAB9ANPC1 | |
| SCHEMBL4573001 | 0.80 | HTT (0.67) | HTTALDH1A1NPSR1RAB9ANPC1 | |
| SCHEMBL1530038 | 0.79 | HTT (0.76) | HTTALDH1A1NPSR1RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0388429-A4 | FURAN AND PYRROLE CONTAINING LIPOXYGENASE INHIBITING COMPOUNDS | — | 1991-08-21 | — | — | EP | disclosed |
| EP-0388429-A1 | FURAN AND PYRROLE CONTAINING LIPOXYGENASE INHIBITING COMPOUNDS | ABBOTT LABORATORIES (US) | 1990-09-26 | — | — | EP | disclosed |
| WO-1989004299-A1 | FURAN AND PYRROLE CONTAINING LIPOXYGENASE INHIBITING COMPOUNDS | ABBOTT LABORATORIES (US) | 1989-05-18 | — | — | WO | disclosed |