Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 2/20 | 0.39 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.39 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CYP4Z1 | Q86W10 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9832157 | 0.90 | SMN1; SMN2 (0.60) | SMN1; SMN2PPARGPOLBALOX5LTA4H | |
| SCHEMBL8911435 | 0.89 | SMN1; SMN2 (0.54) | SMN1; SMN2PPARGPOLBRAB9AALOX5 | |
| SCHEMBL10407546 | 0.89 | SMN1; SMN2 (0.46) | SMN1; SMN2PPARGPOLBALOX5LTA4H | |
| SCHEMBL10408080 | 0.89 | SMN1; SMN2 (0.46) | SMN1; SMN2PPARGPOLBALDH1A1GAA | |
| SCHEMBL10407524 | 0.89 | SMN1; SMN2 (0.46) | SMN1; SMN2PPARGPOLBRAB9AALOX5 | |
| SCHEMBL9831883 | 0.85 | SMN1; SMN2 (0.44) | SMN1; SMN2PPARGPOLBALOX5LTA4H | |
| SCHEMBL9832038 | 0.85 | SMN1; SMN2 (0.45) | SMN1; SMN2PPARGRAB9AALOX5LTA4H | |
| SCHEMBL10407598 | 0.83 | SMN1; SMN2 (0.44) | SMN1; SMN2PPARGALOX5LTA4HCYP4F2 | |
| SCHEMBL9829514 | 0.83 | SMN1; SMN2 (0.50) | SMN1; SMN2RAB9AALOX5LTA4HALDH1A1 | |
| SCHEMBL10407410 | 0.82 | CETP (0.45) | SMN1; SMN2PPARGALOX5CYP4F2CYP4A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449989-A1 | 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES | Sloan-Kettering Institute For Cancer Research (US) | 1991-10-09 | — | — | EP | disclosed |
| WO-1990007496-A1 | 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-07-12 | — | — | WO | disclosed |
| US-4925939-A | 6,7-dihydropyrrol[3,4-c]pyrido[2,3-d]pyrimidine derivatives | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-05-15 | — | — | US | disclosed |