Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1C | Q13936 | 12/20 | 0.77 |
| ▸ | CACNA1F | O60840 | 11/20 | 0.77 |
| ▸ | CACNA1D | Q01668 | 11/20 | 0.77 |
| ▸ | CACNA1S | Q13698 | 11/20 | 0.77 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.77 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.72 |
| ▸ | MEN1 | O00255 | 3/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.72 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.72 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.72 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.72 |
| ▸ | MAPT | P10636 | 2/20 | 0.72 |
| ▸ | LMNA | P02545 | 1/20 | 0.72 |
| ▸ | POLB | P06746 | 1/20 | 0.72 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.72 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.72 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.72 |
| ▸ | TSHR | P16473 | 1/20 | 0.72 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9832517 | 1.00 | CACNA1C (0.77) | CACNA1CCACNA1FCACNA1DCACNA1SADORA3 | |
| SCHEMBL9833214 | 0.97 | CACNA1C (0.72) | CACNA1CCACNA1FCACNA1DCACNA1SADORA3 | |
| SCHEMBL9833218 | 0.97 | CACNA1C (0.72) | CACNA1CCACNA1FCACNA1DCACNA1SADORA3 | |
| SCHEMBL9832526 | 0.95 | CACNA1B (0.69) | CACNA1CCACNA1FCACNA1DCACNA1SADORA3 | |
| SCHEMBL9832530 | 0.95 | CACNA1B (0.69) | CACNA1CCACNA1FCACNA1DCACNA1SADORA3 | |
| SCHEMBL9832365 | 0.94 | CACNA1C (0.69) | CACNA1CCACNA1FCACNA1DCACNA1SADORA3 | |
| SCHEMBL9832371 | 0.94 | CACNA1C (0.69) | CACNA1CCACNA1FCACNA1DCACNA1SADORA3 | |
| SCHEMBL9833643 | 0.94 | MEN1 (0.74) | CACNA1CCACNA1FCACNA1DCACNA1SADORA3 | |
| SCHEMBL9401501 | 0.94 | CACNA1B (0.78) | CACNA1CCACNA1FCACNA1DCACNA1SADORA3 | |
| SCHEMBL9832499 | 0.94 | CACNA1B (0.78) | CACNA1CCACNA1FCACNA1DCACNA1SADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0161877-B1 | 1,4-DIHYDROPYRIDINE DERIVATIVES, METHODS FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME | FUJIREBIO KABUSHIKI KAISHA also trading as FUJIREBIO INC. (JP) | 1991-05-29 | — | — | EP | disclosed |
| US-4672068-A | Antihypertensive 1,4-dihydropyridines having a conjugated ester | FUJIREBIO KABUSHIKI KAISHA (JP) | 1987-06-09 | — | — | US | disclosed |
| EP-0161877-A2 | 1,4-dihydropyridine derivatives, methods for their production and pharmaceutical compositions comprising the same | FUJIREBIO KABUSHIKI KAISHA also trading as FUJIREBIO INC. (JP) | 1985-11-21 | — | — | EP | disclosed |