Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10686678 | 0.93 | PPARG (0.53) | PPARGALOX15SMN1; SMN2ALDH1A1L3MBTL1 | |
| SCHEMBL15483651 | 0.90 | PPARG (0.63) | PPARGALOX15SMN1; SMN2ALDH1A1L3MBTL1 | |
| SCHEMBL15004697 | 0.90 | PPARG (0.62) | PPARGALOX15SMN1; SMN2ALDH1A1L3MBTL1 | |
| SCHEMBL9831770 | 0.86 | PPARG (0.50) | PPARGALOX15SMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL9831443 | 0.85 | PPARG (0.50) | PPARGSMN1; SMN2ALDH1A1LMNAKMT2A | |
| SCHEMBL16171348 | 0.84 | PPARG (0.57) | PPARGALOX15SMN1; SMN2ALDH1A1L3MBTL1 | |
| SCHEMBL8031629 | 0.84 | PPARG (0.64) | PPARGALOX15SMN1; SMN2ALDH1A1L3MBTL1 | |
| SCHEMBL9831449 | 0.84 | SMN1; SMN2 (0.61) | PPARGSMN1; SMN2ALDH1A1L3MBTL1LTA4H | |
| SCHEMBL15004937 | 0.83 | PPARG (0.56) | PPARGALOX15SMN1; SMN2ALDH1A1L3MBTL1 | |
| SCHEMBL10395065 | 0.81 | PPARG (0.44) | PPARGALOX15SMN1; SMN2ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449989-A1 | 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES | Sloan-Kettering Institute For Cancer Research (US) | 1991-10-09 | — | — | EP | disclosed |
| WO-1990007496-A1 | 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-07-12 | — | — | WO | disclosed |
| US-4925939-A | 6,7-dihydropyrrol[3,4-c]pyrido[2,3-d]pyrimidine derivatives | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-05-15 | — | — | US | disclosed |