Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 8/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.43 |
| ▸ | HTT | P42858 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | CRHBP | P24387 | 2/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9832804 | 1.00 | MAPT (0.50) | MAPTCYP1A2CYP3A4CYP2C9ALOX12 | |
| SCHEMBL9833843 | 0.92 | MAPT (0.48) | MAPTCYP1A2CYP3A4CYP2C9ALOX12 | |
| SCHEMBL9834127 | 0.92 | MAPT (0.48) | MAPTCYP1A2CYP3A4CYP2C9ALOX12 | |
| SCHEMBL9833839 | 0.92 | MAPT (0.48) | MAPTCYP1A2CYP3A4CYP2C9ALOX12 | |
| SCHEMBL9834131 | 0.92 | MAPT (0.48) | MAPTCYP1A2CYP3A4CYP2C9ALOX12 | |
| SCHEMBL9832362 | 0.80 | MEN1 (0.39) | MAPTCYP3A4MEN1KMT2AHTT | |
| SCHEMBL9833446 | 0.80 | MAPT (0.48) | MAPTCYP1A2CYP3A4CYP2C9ALOX12 | |
| SCHEMBL9833441 | 0.80 | MAPT (0.48) | MAPTCYP1A2CYP3A4CYP2C9ALOX12 | |
| SCHEMBL6816339 | 0.76 | MAPT (0.49) | MAPTCYP1A2CYP3A4CYP2C9ALOX12 | |
| SCHEMBL6816346 | 0.76 | MAPT (0.49) | MAPTCYP1A2CYP3A4CYP2C9ALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0205272-B1 | CINNOLINE DERIVATIVES | ICI AMERICAS INC. (US) | 1991-08-14 | — | — | EP | disclosed |
| US-4886800-A | Substituted cinnoline derivatives as CNS depressants | ICI AMERICAS INC. (US) | 1989-12-12 | — | — | US | disclosed |
| EP-0205272-A2 | Cinnoline derivatives | ICI AMERICAS INC. (US) | 1986-12-17 | — | — | EP | disclosed |