Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GMNN | O75496 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | PTAFR | P25105 | 1/20 | 0.48 |
| ▸ | MTOR | P42345 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL9829779 | 1.00 | GMNN (0.48) | GMNNUSP2LMNAPTAFRMTOR | |
| Bromide SCHEMBL9829313 | 1.00 | GMNN (0.48) | GMNNUSP2LMNAPTAFRMTOR | |
| Bromide SCHEMBL9828491 | 1.00 | GMNN (0.48) | GMNNUSP2LMNAPTAFRMTOR | |
| Bromide SCHEMBL9828050 | 1.00 | GMNN (0.48) | GMNNUSP2LMNAPTAFRMTOR | |
| Bromide SCHEMBL9829840 | 1.00 | GMNN (0.48) | GMNNUSP2LMNAPTAFRMTOR | |
| SCHEMBL9829480 | 0.99 | GMNN (0.49) | GMNNUSP2LMNAPTAFRMTOR | |
| SCHEMBL9828360 | 0.99 | GMNN (0.49) | GMNNUSP2LMNAPTAFRMTOR | |
| Hydrochloric Acid SCHEMBL9828797 | 0.98 | GMNN (0.48) | GMNNUSP2LMNAPTAFRMTOR | |
| Iodide SCHEMBL9828286 | 0.98 | GMNN (0.48) | GMNNUSP2LMNAPTAFRMTOR | |
| Bromide SCHEMBL9829652 | 0.94 | GMNN (0.52) | GMNNUSP2LMNAPTAFRMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0247201-B1 | PROPANE-1,3-DIOL DERIVATIVES, A METHOD FOR THEIR PRODUCTION AND A PHARMACEUTICAL COMPOSITION | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB) (DK) | 1991-05-15 | — | — | EP | disclosed |
| US-4945098-A | Novel propane-1,3-diol derivatives and use | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB) (DK) | 1990-07-31 | — | — | US | disclosed |