Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1B | Q00975 | 16/20 | 0.65 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | MLNR | O43193 | 1/20 | 0.53 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.53 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.53 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.53 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.53 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.53 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9833501 | 1.00 | CACNA1B (0.65) | CACNA1BADORA3HTTMEN1MLNR | |
| SCHEMBL9830577 | 0.86 | CACNA1B (0.63) | CACNA1BADORA3HTTMEN1MLNR | |
| SCHEMBL9830581 | 0.86 | CACNA1B (0.63) | CACNA1BADORA3HTTMEN1MLNR | |
| SCHEMBL9831100 | 0.85 | CACNA1B (0.61) | CACNA1BADORA3HTTMEN1MLNR | |
| SCHEMBL9831094 | 0.85 | CACNA1B (0.61) | CACNA1BADORA3HTTMEN1MLNR | |
| SCHEMBL11776554 | 0.85 | KDM4E (0.56) | CACNA1BADORA3MEN1NR1I2NR3C1 | |
| SCHEMBL10719900 | 0.84 | CACNA1B (0.87) | CACNA1BADORA3HTTMEN1MLNR | |
| SCHEMBL10719905 | 0.84 | CACNA1B (0.87) | CACNA1BADORA3HTTMEN1MLNR | |
| SCHEMBL2615090 | 0.83 | NR1I2 (0.65) | CACNA1BADORA3MEN1NR1I2NR3C1 | |
| SCHEMBL29676427 | 0.83 | NR1I2 (0.65) | CACNA1BADORA3MEN1NR1I2NR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0161877-B1 | 1,4-DIHYDROPYRIDINE DERIVATIVES, METHODS FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME | FUJIREBIO KABUSHIKI KAISHA also trading as FUJIREBIO INC. (JP) | 1991-05-29 | — | — | EP | disclosed |
| US-4672068-A | Antihypertensive 1,4-dihydropyridines having a conjugated ester | FUJIREBIO KABUSHIKI KAISHA (JP) | 1987-06-09 | — | — | US | disclosed |
| EP-0161877-A2 | 1,4-dihydropyridine derivatives, methods for their production and pharmaceutical compositions comprising the same | FUJIREBIO KABUSHIKI KAISHA also trading as FUJIREBIO INC. (JP) | 1985-11-21 | — | — | EP | disclosed |