SCHEMBL9833799

SCHEMBL9833799

COc1cc(NC(=O)Cl)ccc1Cl

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GRM4 Q14833 2/20 0.61
HDAC6 Q9UBN7 1/20 0.61
MAPT P10636 4/20 0.55
MEN1 O00255 2/20 0.55
KMT2A Q03164 2/20 0.55
MAOB P27338 3/20 0.54
MAOA P21397 1/20 0.51
SMN1; SMN2 Q16637 3/20 0.50
TP53 P04637 2/20 0.50
PKM P14618 1/20 0.50
HPGD P15428 1/20 0.50
NPSR1 Q6W5P4 1/20 0.50
HTT P42858 2/20 0.49
ALDH1A1 P00352 2/20 0.49
GLA P06280 1/20 0.49
KDM4E B2RXH2 1/20 0.48
NPC1 O15118 2/20 0.48
RAB9A P51151 2/20 0.48
POLB P06746 1/20 0.48
CYP1A2 P05177 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9730182 0.86 GRM4 (0.61) GRM4HDAC6MAPTMEN1KMT2A
SCHEMBL27413036 0.85 GRM4 (0.59) GRM4HDAC6MAPTMEN1KMT2A
SCHEMBL1504084 0.83 GRM4 (0.58) GRM4HDAC6MAPTMEN1KMT2A
SCHEMBL1504233 0.83 GRM4 (0.58) GRM4HDAC6MAPTMEN1KMT2A
SCHEMBL31184650 0.83 GRM4 (0.61) GRM4MAPTMEN1KMT2ASMN1; SMN2
SCHEMBL9731379 0.82 CYP3A4 (0.69) GRM4HDAC6MEN1KMT2AHTT
SCHEMBL6493991 0.82 GRM4 (0.57) GRM4HDAC6MAPTMEN1KMT2A
SCHEMBL5796044 0.82 GRM4 (0.57) GRM4HDAC6MAPTMEN1KMT2A
SCHEMBL344338 0.82 GRM4 (0.57) GRM4HDAC6MAPTMEN1KMT2A
SCHEMBL9298899 0.81 HPGD (0.67) GRM4HDAC6MAPTSMN1; SMN2HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0241559-B1 OXAZOLIDINEDIONE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND HERBICIDES CONTAINING THE SAME SAGAMI CHEMICAL RESEARCH CENTER (JP) 1991-10-30 EP disclosed
US-4983751-A Chemical intermediates SAGAMI CHEMICAL RESEARCH CENTER (JP) 1991-01-08 US disclosed
US-4818272-A NONPHYTOTOXICITY FOR CROPS HELICAL STREAMS SAGAMI CHEMICAL RESEARCH CENTER (JP) 1989-04-04 US disclosed
EP-0241559-A1 OXAZOLIDINEDIONE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND HERBICIDES CONTAINING THE SAME SAGAMI CHEMICAL RESEARCH CENTER (JP) 1987-10-21 EP disclosed