Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 6/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.43 |
| ▸ | TYR | P14679 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9834016 | 1.00 | KDM4E (0.61) | KDM4EHSD17B10MAPTL3MBTL1SMN1; SMN2 | |
| SCHEMBL973060 | 0.83 | KDM4E (0.69) | KDM4EHSD17B10MAPTL3MBTL1SMN1; SMN2 | |
| SCHEMBL4883834 | 0.81 | KDM4E (0.61) | KDM4EHSD17B10MAPTL3MBTL1SMN1; SMN2 | |
| SCHEMBL4883820 | 0.81 | KDM4E (0.61) | KDM4EHSD17B10MAPTL3MBTL1SMN1; SMN2 | |
| SCHEMBL12947791 | 0.79 | KDM4E (0.67) | KDM4EHSD17B10MAPTL3MBTL1SMN1; SMN2 | |
| SCHEMBL6296341 | 0.78 | KDM4E (0.57) | KDM4EHSD17B10MAPTL3MBTL1SMN1; SMN2 | |
| SCHEMBL6296340 | 0.78 | KDM4E (0.57) | KDM4EHSD17B10MAPTL3MBTL1SMN1; SMN2 | |
| SCHEMBL4891163 | 0.77 | KDM4E (0.53) | KDM4EHSD17B10MAPTL3MBTL1SMN1; SMN2 | |
| SCHEMBL4891174 | 0.77 | KDM4E (0.53) | KDM4EHSD17B10MAPTL3MBTL1SMN1; SMN2 | |
| SCHEMBL974413 | 0.77 | KDM4E (0.56) | KDM4EHSD17B10MAPTL3MBTL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0224919-B1 | NEW THIAZOLE COMPOUNDS, PROCESSES FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-08-14 | — | — | EP | disclosed |
| US-4742057-A | Antiallergic thiazole compounds | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-05-03 | — | — | US | disclosed |
| EP-0224919-A2 | New thiazole compounds, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1987-06-10 | — | — | EP | disclosed |