Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.43 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 2/20 | 0.39 |
| ▸ | TDO2 | P48775 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9837308 | 0.84 | NPC1 (0.43) | L3MBTL1KDM4ETDP1NPC1RAB9A | |
| SCHEMBL10517143 | 0.79 | MAPT (0.52) | MAPTALDH1A1L3MBTL1KDM4ENLRP3 | |
| SCHEMBL9834046 | 0.76 | MAPT (0.47) | MAPTALDH1A1L3MBTL1KDM4ENLRP3 | |
| SCHEMBL1461839 | 0.71 | MAPT (0.56) | MAPTALDH1A1L3MBTL1KDM4ENLRP3 | |
| SCHEMBL6297845 | 0.70 | MAPT (0.59) | MAPTALDH1A1L3MBTL1KDM4ENLRP3 | |
| SCHEMBL7093706 | 0.70 | MAPT (0.55) | MAPTALDH1A1L3MBTL1KDM4ENLRP3 | |
| SCHEMBL10507663 | 0.69 | MAPT (0.52) | MAPTALDH1A1L3MBTL1KDM4ENLRP3 | |
| SCHEMBL28689662 | 0.67 | MAPT (0.52) | MAPTALDH1A1L3MBTL1KDM4ENLRP3 | |
| SCHEMBL30292810 | 0.67 | MAPT (0.52) | MAPTALDH1A1L3MBTL1KDM4ENLRP3 | |
| SCHEMBL7681777 | 0.66 | MAPT (0.58) | MAPTALDH1A1L3MBTL1KDM4ENLRP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0276500-B1 | 2-OXINDOLE INTERMEDIATES | PFIZER INC. (US) | 1991-05-15 | — | — | EP | disclosed |
| EP-0155828-B1 | PROCESS FOR MAKING 2-OXINDOLE-1-CARBOXAMIDES AND INTERMEDIATES THEREFOR | PFIZER INC. (US) | 1990-09-19 | — | — | EP | disclosed |
| EP-0156603-B1 | 3-SUBSTITUTED 2-OXINDOLE-1-CARBOXAMIDES AS ANALGESIC AND ANTI-INFLAMMATORY AGENTS | PFIZER INC. (US) | 1989-08-23 | — | — | EP | disclosed |
| EP-0164860-B1 | N,3-DISUBSTITUTED 2-OXINDOLE-1-CARBOXAMIDES AS ANALGESIC AND ANTIINFLAMMATORY AGENTS | PFIZER INC. (US) | 1989-07-05 | — | — | EP | disclosed |
| EP-0175551-B1 | ANALGESIC AND ANTIINFLAMMATORY 1,3-DIACYL-2-OXINDOLE COMPOUNDS | PFIZER INC. (US) | 1989-05-10 | — | — | EP | disclosed |
| EP-0153818-B1 | 1,3-DISUBSTITUTED 2-OXINDOLES AS ANALGESIC AND ANTI-INFLAMMATORY AGENTS | PFIZER INC. (US) | 1989-03-15 | — | — | EP | disclosed |
| US-4808601-A | Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds | PFIZER INC. (US) | 1989-02-28 | — | — | US | disclosed |
| EP-0276500-A2 | 2-Oxindole intermediates | PFIZER INC. (US) | 1988-08-03 | — | — | EP | disclosed |
| US-4752609-A | Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds | PFIZER INC. (US) | 1988-06-21 | — | — | US | disclosed |
| US-4721712-A | 1,3-disubstituted 2-oxindoles as analgesic and anti-inflammatory agents | PFIZER INC. (US) | 1988-01-26 | — | — | US | disclosed |
| US-4665194-A | ANALGESICS, ANTIINFLAMMATORY AGENTS | PFIZER INC. (US) | 1987-05-12 | — | — | US | disclosed |
| US-4658037-A | RHEUMATIC DISEASES | PFIZER INC. (US) | 1987-04-14 | — | — | US | disclosed |
| US-4652658-A | Process for making 2-oxindole-1-carboxamides and intermediates therefor | PFIZER INC. (US) | 1987-03-24 | — | — | US | disclosed |
| EP-0175551-A1 | Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds | PFIZER INC. (US) | 1986-03-26 | — | — | EP | disclosed |
| US-4569942-A | N,3-Disubstituted 2-oxindole-1-carboxamides as analgesic and antiinflammatory agents | PFIZER INC. (US) | 1986-02-11 | — | — | US | disclosed |
| EP-0164860-A1 | N,3-disubstituted 2-oxindole-1-carboxamides as analgesic and antiinflammatory agents | PFIZER INC. (US) | 1985-12-18 | — | — | EP | disclosed |
| US-4556672-A | 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents | PFIZER INC. (US) | 1985-12-03 | — | — | US | disclosed |
| EP-0156603-A2 | 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents | PFIZER INC. (US) | 1985-10-02 | — | — | EP | disclosed |
| EP-0155828-A2 | Process for making 2-oxindole-1-carboxamides and intermediates therefor | PFIZER INC. (US) | 1985-09-25 | — | — | EP | disclosed |
| EP-0153818-A2 | 1,3-Disubstituted 2-oxindoles as analgesic and anti-inflammatory agents | PFIZER INC. (US) | 1985-09-04 | — | — | EP | disclosed |