Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 1/20 | 0.48 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9836086 | 1.00 | ESR2 (0.48) | ESR2NR1H2ADORA1USP2SMN1; SMN2 | |
| SCHEMBL3314000 | 0.90 | USP2 (0.49) | ESR2NR1H2ADORA1USP2SMN1; SMN2 | |
| SCHEMBL4185350 | 0.87 | USP2 (0.43) | ESR2NR1H2USP2SMN1; SMN2MAPK1 | |
| SCHEMBL9426285 | 0.84 | ESR2 (0.50) | ESR2NR1H2ADORA1USP2SMN1; SMN2 | |
| SCHEMBL27404495 | 0.84 | ESR2 (0.50) | ESR2NR1H2ADORA1USP2SMN1; SMN2 | |
| SCHEMBL9426289 | 0.84 | ESR2 (0.50) | ESR2NR1H2ADORA1USP2SMN1; SMN2 | |
| SCHEMBL27557006 | 0.84 | ADORA1 (0.46) | ESR2NR1H2ADORA1USP2SMN1; SMN2 | |
| SCHEMBL25081026 | 0.81 | USP2 (0.55) | ESR2NR1H2ADORA1USP2SMN1; SMN2 | |
| SCHEMBL27788400 | 0.81 | ESR2 (0.45) | ESR2NR1H2ADORA1USP2SMN1; SMN2 | |
| SCHEMBL5510653 | 0.80 | HPGD (0.44) | USP2SMN1; SMN2MAPK1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100564378-C | Bi Ka Wan oxadiazole and thiadiazoles derivative | APPLIED RESEARCH SYSTEMS (CH) | 2009-12-02 | — | — | CN | disclosed |
| CN-1296354-C | Pharmaceutically active pyrrolidine derivatives | APPLIED RES SYSTEMS AKS HOLDIN (AN) | 2007-01-24 | — | — | CN | disclosed |
| CN-1639155-A | Pyrrolidine oxadiazole- and thiadiazole derivatives | APPLIED RESEARCH SYSTEMS (AN) | 2005-07-13 | — | — | CN | disclosed |
| CN-1419541-A | Pharmaceutically active pyrrolidine derivatives as BAX inhibitors | APPLIED RES SYSTEMS AKS HOLDIN (NL) | 2003-05-21 | — | — | CN | disclosed |
| EP-0202048-B1 | CARBAPENEM DERIVATIVES, THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SANKYO COMPANY LIMITED (JP) | 1991-10-30 | — | — | EP | disclosed |
| US-4771046-A | ANTIBIOTICS | SANKYO COMPANY, LIMITED (JP) | 1988-09-13 | — | — | US | disclosed |
| EP-0202048-A1 | Carbapenem derivatives, their preparation, and pharmaceutical compositions containing them | SANKYO COMPANY LIMITED (JP) | 1986-11-20 | — | — | EP | disclosed |