Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1C | Q13936 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.48 |
| ▸ | THPO | P40225 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.48 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.47 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10926570 | 0.92 | MEN1 (0.49) | CACNA1CMEN1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL10975735 | 0.92 | CACNA1C (0.55) | CACNA1CMEN1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL10912932 | 0.90 | MEN1 (0.54) | CACNA1CMEN1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL9636791 | 0.86 | MAPT (0.63) | CACNA1CMEN1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL31069038 | 0.86 | MAPT (0.63) | CACNA1CMEN1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL10769099 | 0.85 | MEN1 (0.48) | CACNA1CMEN1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL10352579 | 0.84 | MEN1 (0.61) | CACNA1CMEN1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL11135654 | 0.82 | CACNA1C (0.59) | CACNA1CMEN1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL10769693 | 0.82 | NR3C2 (0.48) | CACNA1CMEN1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL11007384 | 0.81 | MEN1 (0.62) | CACNA1CMEN1CYP1A2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0231511-B1 | 4-AMINOARYLDIHYDROPYRIDINE LACTONES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN MEDICAMENTS | BAYER AG (DE) | 1991-04-10 | — | — | EP | disclosed |
| EP-0231511-A1 | 4-Aminoaryldihydropyridine lactones, process for their preparation and their use in medicaments | BAYER AG (DE) | 1987-08-12 | — | — | EP | disclosed |
| EP-0088938-A1 | Use of pyridine compounds for the manufacture of medicaments with an antihypoxemia and ischemia-protective activity | BAYER AG (DE) | 1983-09-21 | — | — | EP | disclosed |