Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | YAP1 | P46937 | 1/20 | 0.42 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10378518 | 0.86 | EPHX1 (0.50) | EPHX1GAARAB9ATSHRSMN1; SMN2 | |
| SCHEMBL9838823 | 0.86 | EPHX1 (0.50) | EPHX1GAARAB9ALMNATSHR | |
| SCHEMBL27691760 | 0.86 | EPHX1 (0.50) | EPHX1GAARAB9ATSHRSMN1; SMN2 | |
| SCHEMBL9839052 | 0.84 | EPHX1 (0.48) | EPHX1GAARAB9ALMNATSHR | |
| SCHEMBL27691912 | 0.84 | EPHX1 (0.48) | EPHX1GAARAB9ATSHRSMN1; SMN2 | |
| SCHEMBL10379789 | 0.84 | EPHX1 (0.48) | EPHX1GAARAB9ATSHRSMN1; SMN2 | |
| SCHEMBL9837874 | 0.84 | EPHX1 (0.48) | EPHX1GAARAB9ALMNATSHR | |
| SCHEMBL9838802 | 0.84 | EPHX1 (0.48) | EPHX1GAARAB9ALMNATSHR | |
| SCHEMBL9837592 | 0.83 | EPHX1 (0.47) | EPHX1GAARAB9ALMNATSHR | |
| SCHEMBL9837860 | 0.82 | EPHX1 (0.46) | EPHX1GAARAB9ATSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0276122-B1 | CYCLOALKYL-SUBSTITUTED 4-AMINOPHENYL HALO DERIVATIVES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.r.l. (IT) | 1991-08-07 | — | — | EP | disclosed |
| US-4847295-A | ANTITUMOR AGENTS | FARMITALIA CARLO ERBA S.R.L. (IT) | 1989-07-11 | — | — | US | disclosed |
| EP-0276122-A2 | Cycloalkyl-substituted 4-aminophenyl halo derivatives and process for their preparation | FARMITALIA CARLO ERBA S.r.l. (IT) | 1988-07-27 | — | — | EP | disclosed |