Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | HPGD | P15428 | 4/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.57 |
| ▸ | ALB | P02768 | 1/20 | 0.57 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.57 |
| ▸ | TUBB4A | P04350 | 6/20 | 0.56 |
| ▸ | TUBB | P07437 | 6/20 | 0.56 |
| ▸ | TUBA3C | P0DPH7 | 6/20 | 0.56 |
| ▸ | TUBA1B | P68363 | 6/20 | 0.56 |
| ▸ | TUBA4A | P68366 | 6/20 | 0.56 |
| ▸ | TUBB4B | P68371 | 6/20 | 0.56 |
| ▸ | TUBB3 | Q13509 | 6/20 | 0.56 |
| ▸ | TUBB2A | Q13885 | 6/20 | 0.56 |
| ▸ | TUBB8 | Q3ZCM7 | 6/20 | 0.56 |
| ▸ | TUBA3E | Q6PEY2 | 6/20 | 0.56 |
| ▸ | TUBA1A | Q71U36 | 6/20 | 0.56 |
| ▸ | TUBA1C | Q9BQE3 | 6/20 | 0.56 |
| ▸ | TUBB6 | Q9BUF5 | 6/20 | 0.56 |
| ▸ | TUBB2B | Q9BVA1 | 6/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4186238 | 1.00 | KDM4E (0.57) | KDM4EALDH1A1HPGDHSD17B10ALB | |
| SCHEMBL9837887 | 0.92 | KDM4E (0.47) | KDM4EALDH1A1HPGDHSD17B10ALB | |
| SCHEMBL4187944 | 0.91 | KDM4E (0.46) | KDM4EALDH1A1HPGDHSD17B10ALB | |
| SCHEMBL9838874 | 0.91 | KDM4E (0.46) | KDM4EALDH1A1HPGDHSD17B10ALB | |
| SCHEMBL4190220 | 0.87 | KDM4E (0.45) | KDM4EALDH1A1HPGDHSD17B10ALB | |
| SCHEMBL13946231 | 0.87 | KDM4E (0.45) | KDM4EALDH1A1HPGDHSD17B10ALB | |
| SCHEMBL9838896 | 0.86 | KDM4E (0.44) | KDM4EALDH1A1HPGDHSD17B10ALB | |
| SCHEMBL4186230 | 0.86 | PIM1 (0.46) | KDM4EALDH1A1HPGDHSD17B10ALB | |
| SCHEMBL14042223 | 0.86 | KDM4E (0.42) | KDM4EALDH1A1HPGDHSD17B10ALB | |
| SCHEMBL9839253 | 0.86 | PIM1 (0.46) | KDM4EALDH1A1HPGDHSD17B10ALB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0228661-B1 | ISOXAZOLO-PYRIDO-BENZOXAZINE AND ISOTHIAZOLO-PYRIDO-BENZOXAZINE DERIVATIVES | ABBOTT LABORATORIES (US) | 1991-08-07 | — | — | EP | disclosed |
| US-4687770-A | Isoxazolo-pyrido-benzoxazine and isothiazolo-pyrido-benzoxazine derivatives | ABBOTT LABORATORIES (US) | 1987-08-18 | — | — | US | disclosed |
| EP-0228661-A1 | Isoxazolo-pyrido-benzoxazine and isothiazolo-pyrido-benzoxazine derivatives | ABBOTT LABORATORIES (US) | 1987-07-15 | — | — | EP | disclosed |