SCHEMBL984

SCHEMBL984

Cn1c2c(c3ccccc31)C(=O)CC2

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 2/20 0.54
HTR2C P28335 2/20 0.54
HSD17B10 Q99714 3/20 0.53
KDM4E B2RXH2 3/20 0.53
ALOX15 P16050 1/20 0.53
MAPK1 P28482 1/20 0.53
CYP1A2 P05177 3/20 0.49
CYP2D6 P10635 2/20 0.49
GPR3 P46089 1/20 0.47
ALDH1A1 P00352 2/20 0.46
TSHR P16473 1/20 0.46
KCNH2 Q12809 4/20 0.45
CYP3A4 P08684 3/20 0.44
HTR2B P41595 2/20 0.44
HTR3A P46098 2/20 0.44
HTR3E A5X5Y0 1/20 0.44
SLC22A2 O15244 1/20 0.44
SLC22A1 O15245 1/20 0.44
SLC22A3 O75751 1/20 0.44
HTR3B O95264 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1146660 0.90 HTR2A (0.51) HTR2AHTR2CHSD17B10KDM4EALOX15
SCHEMBL7428637 0.90 HTR2A (0.51) HTR2AHTR2CHSD17B10KDM4EALOX15
SCHEMBL30223533 0.90 HTR2A (0.51) HTR2AHTR2CHSD17B10KDM4EALOX15
SCHEMBL3549753 0.80 HTR2A (0.45) HTR2AHTR2CHSD17B10KDM4EALOX15
SCHEMBL13324130 0.79 TP53 (0.46) HTR2AHTR2CHSD17B10KDM4EALOX15
SCHEMBL16201640 0.78 CSNK2B (0.47) HTR2AHTR2CMAPK1CYP1A2ALDH1A1
SCHEMBL13157509 0.78 KCNH2 (0.54) HTR2AHTR2CHSD17B10KDM4EALOX15
SCHEMBL918 0.78 BRD4 (0.57) HTR2AHTR2CHSD17B10KDM4EALOX15
SCHEMBL13157508 0.77 KCNH2 (0.55) HTR2AHTR2CHSD17B10KDM4EALOX15
Hydrochloric Acid SCHEMBL6625465 0.77 KDM4E (0.47) HSD17B10KDM4EALDH1A1CREBBPLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5360800-A Tetrahydro-1H-pyrido[4,3-b]indol-1-one derivatives GLAXO GROUP LIMITED (GB) 1994-11-01 US disclosed
US-4985422-A TRICYCLIC, IMIDAZOLE SUBSTITUTED, ANTAGONIST OF HYDROXYTRYPTAMINE RECEPTORS, PSYCHOTIC DISORDERS, SCHIZOPHRENIA GLAXO GROUP LIMITED (GB) 1991-01-15 US disclosed
US-4939144-A PSYCHOLOGICAL DISORDERS; ANXIOLYTIC AND ANTIEMETIC AGENTS GLAXO GROUP LIMITED (GB) 1990-07-03 US disclosed
EP-0317088-A1 Ketone derivatives GLAXO GROUP LIMITED (GB) 1989-05-24 EP disclosed