Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | HTR3A | P46098 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | BCHE | P06276 | 1/20 | 0.30 |
| ▸ | SCN1A | P35498 | 1/20 | 0.30 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6978506 | 0.71 | MEN1 (0.42) | KMT2AMEN1POLBCYP2D6LMNA | |
| SCHEMBL13017470 | 0.70 | POLB (0.45) | KMT2AMEN1POLBCYP2D6LMNA | |
| SCHEMBL789797 | 0.70 | KMT2A (0.45) | KMT2AMEN1POLBCYP2D6LMNA | |
| Hydrochloric Acid SCHEMBL3205113 | 0.68 | KMT2A (0.43) | KMT2AMEN1POLBCYP2D6LMNA | |
| SCHEMBL6958551 | 0.67 | MEN1 (0.38) | KMT2AMEN1POLBCYP2D6LMNA | |
| SCHEMBL3267719 | 0.67 | POLB (0.38) | KMT2AMEN1POLBCYP2D6LMNA | |
| SCHEMBL2181235 | 0.65 | NPSR1 (0.34) | KMT2AMEN1POLBNPSR1 | |
| SCHEMBL13307109 | 0.65 | KMT2A (0.41) | KMT2AMEN1POLBCYP2D6LMNA | |
| Benzene SCHEMBL28869400 | 0.65 | CYP1A2 (0.42) | KMT2AMEN1POLBCYP2D6LMNA | |
| SCHEMBL135077 | 0.65 | MEN1 (0.61) | KMT2AMEN1POLBCYP2D6LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991004260-A2 | 10,11-METHYLENEDIOXY-20(RS)-CAMPTOTHECIN AND 10,11-METHYLENEDIOXY-20(S)-CAMPTOTHECIN ANALOGS | RESEARCH TRIANGLE INSTITUTE (US) | 1991-04-04 | — | — | WO | disclosed |