Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | CNR1 | P21554 | 6/20 | 0.35 |
| ▸ | CNR2 | P34972 | 6/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28931374 | 0.80 | MAPT (0.33) | POLBSMN1; SMN2HPGDPKMALDH1A1 | |
| SCHEMBL6481381 | 0.79 | MAPT (0.35) | CRBNGAACNR1CNR2POLB | |
| SCHEMBL6221696 | 0.79 | MAPT (0.35) | CRBNGAACNR1CNR2POLB | |
| SCHEMBL9149987 | 0.79 | MAPT (0.35) | CRBNGAACNR1CNR2POLB | |
| SCHEMBL141512 | 0.75 | CNR1 (0.35) | CRBNCNR1CNR2PKMKDM4E | |
| SCHEMBL1344189 | 0.75 | MAPK1 (0.36) | CRBNGAACNR1CNR2MAPK1 | |
| SCHEMBL12427257 | 0.75 | MAPK1 (0.34) | CRBNCNR1CNR2MAPK1SMN1; SMN2 | |
| SCHEMBL1344190 | 0.75 | MAPK1 (0.36) | CRBNGAACNR1CNR2MAPK1 | |
| SCHEMBL28540862 | 0.74 | MAPT (0.44) | CRBNPOLBSMN1; SMN2HPGDPKM | |
| SCHEMBL15241560 | 0.72 | MEN1 (0.39) | GAAPOLBMAPK1SMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0421668-A2 | 1,4-Dihydro-4-oxo-3-quinolone derivatives as selectively toxic mammalian antibacterial agents | PFIZER INC. (US) | 1991-04-10 | — | — | EP | disclosed |