Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.71 |
| ▸ | NPC1 | O15118 | 1/20 | 0.71 |
| ▸ | MLNR | O43193 | 1/20 | 0.71 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.71 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.71 |
| ▸ | ESR1 | P03372 | 1/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.71 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.71 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.71 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.71 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.71 |
| ▸ | HTR1A | P08908 | 1/20 | 0.71 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.71 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.71 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.71 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.71 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.71 |
| ▸ | DRD2 | P14416 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30244768 | 1.00 | MEN1 (0.71) | MEN1KMT2ANPC1MLNRNR1I2 | |
| SCHEMBL10991710 | 1.00 | MEN1 (0.71) | MEN1KMT2ANPC1MLNRNR1I2 | |
| SCHEMBL29690838 | 1.00 | MEN1 (0.71) | MEN1KMT2ANPC1MLNRNR1I2 | |
| SCHEMBL10991720 | 1.00 | MEN1 (0.71) | MEN1KMT2ANPC1MLNRNR1I2 | |
| SCHEMBL144554 | 1.00 | MEN1 (0.71) | MEN1KMT2ANPC1MLNRNR1I2 | |
| SCHEMBL144552 | 1.00 | MEN1 (0.71) | MEN1KMT2ANPC1MLNRNR1I2 | |
| SCHEMBL144553 | 1.00 | MEN1 (0.71) | MEN1KMT2ANPC1MLNRNR1I2 | |
| Hydrochloric Acid SCHEMBL7330576 | 0.98 | MEN1 (0.72) | MEN1KMT2ACYP3A4 | |
| Hydrochloric Acid SCHEMBL7330587 | 0.98 | MEN1 (0.72) | MEN1KMT2ACYP3A4 | |
| Hydrochloric Acid SCHEMBL10989815 | 0.98 | MEN1 (0.72) | MEN1KMT2ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5061728-A | Use of 4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine derivatives in the treatment of inflammation and as immunosuppressants | PFIZER INC. (US) | 1991-10-29 | — | — | US | claimed |
| EP-0386997-A2 | Use of 4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine derivatives in the treatment of psychosis, inflammation, and as immunosuppressants | PFIZER INC. (US) | 1990-09-12 | — | — | EP | claimed |
| US-5061728-A | Use of 4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine derivatives in the treatment of inflammation and as immunosuppressants | PFIZER INC. (US) | 1991-10-29 | — | — | US | disclosed |
| EP-0386997-A2 | Use of 4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine derivatives in the treatment of psychosis, inflammation, and as immunosuppressants | PFIZER INC. (US) | 1990-09-12 | — | — | EP | disclosed |