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SCHEMBL9843880

SCHEMBL9843880

CC(C)c1cccc(C(C)C)c1NC(=O)CC(=O)N(C(C)C)C(c1ccccc1)c1ccccc1

nearest known ligand 0.53

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ SOAT1 P35610 3/20 0.53
▸ SOAT2 O75908 2/20 0.53
▸ SMN1; SMN2 Q16637 1/20 0.52
▸ KMT2A Q03164 3/20 0.52
▸ MEN1 O00255 2/20 0.52
▸ LMNA P02545 1/20 0.49
▸ TDP1 Q9NUW8 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9844128 0.79 SOAT1 (0.55) SOAT1SOAT2SMN1; SMN2KMT2AMEN1
SCHEMBL2147650 0.77 KMT2A (0.65) SOAT1SOAT2SMN1; SMN2KMT2AMEN1
SCHEMBL9851048 0.77 KMT2A (0.54) SOAT1SOAT2SMN1; SMN2KMT2AMEN1
SCHEMBL9317463 0.77 SOAT1 (0.67) SOAT1SOAT2SMN1; SMN2KMT2AMEN1
SCHEMBL9843936 0.77 SMN1; SMN2 (0.77) SOAT1SOAT2SMN1; SMN2KMT2AMEN1
SCHEMBL6899771 0.76 SOAT1 (0.62) SOAT1SOAT2SMN1; SMN2KMT2AMEN1
SCHEMBL9844414 0.76 SOAT1 (0.58) SOAT1SOAT2SMN1; SMN2KMT2AMEN1
SCHEMBL9316603 0.76 SOAT1 (0.58) SOAT1SOAT2SMN1; SMN2KMT2AMEN1
SCHEMBL2148218 0.76 SMN1; SMN2 (0.70) SOAT1SOAT2SMN1; SMN2KMT2AMEN1
SCHEMBL9678803 0.75 KMT2A (0.50) SOAT1SOAT2SMN1; SMN2KMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0433662-A2 Acat inhibitors WARNER-LAMBERT COMPANY (US) 1991-06-26 — — EP claimed
EP-0433662-A2 Acat inhibitors WARNER-LAMBERT COMPANY (US) 1991-06-26 — — EP disclosed