Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 16/20 | 0.57 |
| ▸ | CYP11B2 | P19099 | 7/20 | 0.48 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nitric Acid SCHEMBL9845190 | 1.00 | CYP19A1 (0.57) | CYP19A1CYP11B2CYP11B1KCNH2 | |
| SCHEMBL9845187 | 0.97 | CYP19A1 (0.60) | CYP19A1CYP11B2CYP11B1KCNH2 | |
| Nitric Acid SCHEMBL9845216 | 0.92 | CYP19A1 (0.57) | CYP19A1CYP11B2CYP11B1KCNH2 | |
| Nitric Acid SCHEMBL9845218 | 0.92 | CYP19A1 (0.57) | CYP19A1CYP11B2CYP11B1KCNH2 | |
| Nitric Acid SCHEMBL9845213 | 0.84 | CYP19A1 (0.81) | CYP19A1CYP11B2CYP11B1KCNH2 | |
| SCHEMBL9845182 | 0.83 | CYP19A1 (0.54) | CYP19A1CYP11B2CYP11B1KCNH2 | |
| Nitric Acid SCHEMBL9845214 | 0.83 | CYP19A1 (0.59) | CYP19A1CYP11B2CYP11B1KCNH2 | |
| SCHEMBL13529265 | 0.79 | CYP19A1 (0.60) | CYP19A1CYP11B2CYP11B1KCNH2 | |
| SCHEMBL7772876 | 0.77 | CYP19A1 (0.49) | CYP19A1CYP11B2CYP11B1KCNH2 | |
| SCHEMBL9866168 | 0.76 | CYP19A1 (0.46) | CYP19A1CYP11B2CYP11B1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0426225-A2 | (6,7-dihydro-5H-pyrrolo[1,2-c]-imidazol-5-yl)- and (5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl) substituted 1H-benzotriazole derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-05-08 | — | — | EP | disclosed |